Accessory subunits are integral for assembly and function of human mitochondrial complex I

David A. Stroud (), Elliot E. Surgenor, Luke E. Formosa, Boris Reljic, Ann E. Frazier, Marris G. Dibley, Laura D. Osellame, Tegan Stait, Traude H. Beilharz, David R. Thorburn, Agus Salim and Michael T. Ryan ()
Additional contact information
David A. Stroud: Monash Biomedicine Discovery Institute, Monash University
Elliot E. Surgenor: Monash Biomedicine Discovery Institute, Monash University
Luke E. Formosa: Monash Biomedicine Discovery Institute, Monash University
Boris Reljic: La Trobe Institute for Molecular Science, La Trobe University
Ann E. Frazier: Murdoch Childrens Research Institute, Royal Children’s Hospital
Marris G. Dibley: Monash Biomedicine Discovery Institute, Monash University
Laura D. Osellame: Monash Biomedicine Discovery Institute, Monash University
Tegan Stait: Murdoch Childrens Research Institute, Royal Children’s Hospital
Traude H. Beilharz: Monash Biomedicine Discovery Institute, Monash University
David R. Thorburn: Murdoch Childrens Research Institute, Royal Children’s Hospital
Agus Salim: La Trobe University
Michael T. Ryan: Monash Biomedicine Discovery Institute, Monash University

Nature, 2016, vol. 538, issue 7623, 123-126

Abstract: Gene-editing technology and large-scale proteomics are used to provide insights into the modular assembly of the human mitochondrial respiratory chain complex I, as well as identifying new assembly factors.

Date: 2016
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DOI: 10.1038/nature19754

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