Autocrine BDNF–TrkB signalling within a single dendritic spine

Stephen C. Harward, Nathan G. Hedrick, Charles E. Hall, Paula Parra-Bueno, Teresa A. Milner, Enhui Pan, Tal Laviv, Barbara L. Hempstead, Ryohei Yasuda () and James O. McNamara
Additional contact information
Stephen C. Harward: Duke University Medical Center, Research Drive
Nathan G. Hedrick: Duke University Medical Center, Research Drive
Charles E. Hall: Duke University Medical Center, Research Drive
Paula Parra-Bueno: Max Planck Florida Institute for Neuroscience
Teresa A. Milner: Feil Family Brain and Mind Research Institute, Weill Cornell Medicine
Enhui Pan: Duke University Medical Center, Research Drive
Tal Laviv: Max Planck Florida Institute for Neuroscience
Barbara L. Hempstead: Feil Family Brain and Mind Research Institute, Weill Cornell Medicine
Ryohei Yasuda: Duke University Medical Center, Research Drive
James O. McNamara: Duke University Medical Center, Research Drive

Nature, 2016, vol. 538, issue 7623, 99-103

Abstract: Live fluorescent imaging of murine hippocampal slices shows that NMDAR-dependent glutamate signalling leads to postsynaptic BDNF release, with associated signalling of its receptor, TrkB, on the same dendritic spine, suggesting autocrine BDNF signalling.

Date: 2016
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DOI: 10.1038/nature19766

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