XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer

Jimi Kim, Elizabeth McMillan, Hyun Seok Kim, Niranjan Venkateswaran, Gurbani Makkar, Jaime Rodriguez-Canales, Pamela Villalobos, Jasper Edgar Neggers, Saurabh Mendiratta, Shuguang Wei, Yosef Landesman, William Senapedis, Erkan Baloglu, Chi-Wan B. Chow, Robin E. Frink, Boning Gao, Michael Roth, John D. Minna, Dirk Daelemans, Ignacio I. Wistuba, Bruce A. Posner, Pier Paolo Scaglioni and Michael A. White ()
Additional contact information
Jimi Kim: UTSW Medical Center
Elizabeth McMillan: UTSW Medical Center
Hyun Seok Kim: Severance Biomedical Science Institute, Yonsei University College of Medicine
Niranjan Venkateswaran: Internal Medicine, UTSW Medical Center
Gurbani Makkar: UTSW Medical Center
Jaime Rodriguez-Canales: MD Anderson Cancer Center
Pamela Villalobos: MD Anderson Cancer Center
Jasper Edgar Neggers: KU Leuven Department of Microbiology and Immunology
Saurabh Mendiratta: UTSW Medical Center
Shuguang Wei: Biochemistry, UTSW Medical Center
Yosef Landesman: Karyopharm Therapeutics
William Senapedis: Karyopharm Therapeutics
Erkan Baloglu: Karyopharm Therapeutics
Chi-Wan B. Chow: MD Anderson Cancer Center
Robin E. Frink: Hamon Center, UTSW Medical Center
Boning Gao: Hamon Center, UTSW Medical Center
Michael Roth: Biochemistry, UTSW Medical Center
John D. Minna: Hamon Center, UTSW Medical Center
Dirk Daelemans: KU Leuven Department of Microbiology and Immunology
Ignacio I. Wistuba: MD Anderson Cancer Center
Bruce A. Posner: Biochemistry, UTSW Medical Center
Pier Paolo Scaglioni: Internal Medicine, UTSW Medical Center
Michael A. White: UTSW Medical Center

Nature, 2016, vol. 538, issue 7623, 114-117

Abstract: A multi-genomic approach identifies the addiction of KRAS-mutant lung cancer cells to XPO1-dependent nuclear export, offering a new therapeutic opportunity.

Date: 2016
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DOI: 10.1038/nature19771

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