Tissue-specific mutation accumulation in human adult stem cells during life

Francis Blokzijl, Joep de Ligt, Myrthe Jager, Valentina Sasselli, Sophie Roerink, Nobuo Sasaki, Meritxell Huch, Sander Boymans, Ewart Kuijk, Pjotr Prins, Isaac J. Nijman, Inigo Martincorena, Michal Mokry, Caroline L. Wiegerinck, Sabine Middendorp, Toshiro Sato, Gerald Schwank, Edward E. S. Nieuwenhuis, Monique M. A. Verstegen, Luc J. W. van der Laan, Jeroen de Jonge, Jan N. M. IJzermans, Robert G. Vries, Marc van de Wetering, Michael R. Stratton, Hans Clevers, Edwin Cuppen () and Ruben van Boxtel
Additional contact information
Francis Blokzijl: Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht
Joep de Ligt: Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht
Myrthe Jager: Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht
Valentina Sasselli: Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht
Sophie Roerink: Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Nobuo Sasaki: Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht
Meritxell Huch: Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht
Sander Boymans: Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht
Ewart Kuijk: Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht
Pjotr Prins: Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht
Isaac J. Nijman: Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht
Inigo Martincorena: Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Michal Mokry: University Medical Center Utrecht
Caroline L. Wiegerinck: University Medical Center Utrecht
Sabine Middendorp: University Medical Center Utrecht
Toshiro Sato: Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht
Gerald Schwank: Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht
Edward E. S. Nieuwenhuis: University Medical Center Utrecht
Monique M. A. Verstegen: Erasmus MC-University Medical Center
Luc J. W. van der Laan: Erasmus MC-University Medical Center
Jeroen de Jonge: Erasmus MC-University Medical Center
Jan N. M. IJzermans: Erasmus MC-University Medical Center
Robert G. Vries: Foundation Hubrecht Organoid Technology (HUB)
Marc van de Wetering: Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht
Michael R. Stratton: Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Hans Clevers: Hubrecht Institute for Developmental Biology and Stem Cell Research, KNAW and University Medical Center Utrecht
Edwin Cuppen: Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht
Ruben van Boxtel: Center for Molecular Medicine, Cancer Genomics Netherlands, University Medical Center Utrecht

Nature, 2016, vol. 538, issue 7624, 260-264

Abstract: Stem cells of the liver, colon and small intestine gradually accumulate mutations throughout life at a similar rate even though cancer incidence varies greatly among these tissues.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (10)

Downloads: (external link)
https://www.nature.com/articles/nature19768 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:538:y:2016:i:7624:d:10.1038_nature19768

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature19768

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().