The evolution of Ebola virus: Insights from the 2013–2016 epidemic

Edward C. Holmes (), Gytis Dudas, Andrew Rambaut and Kristian G. Andersen ()
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Edward C. Holmes: Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and Sydney Medical School, Charles Perkins Centre, University of Sydney
Gytis Dudas: Fred Hutchinson Cancer Research Center
Andrew Rambaut: Institute of Evolutionary Biology, Ashworth Laboratories, University of Edinburgh
Kristian G. Andersen: The Scripps Research Institute, La Jolla

Nature, 2016, vol. 538, issue 7624, 193-200

Abstract: Abstract The 2013–2016 epidemic of Ebola virus disease in West Africa was of unprecedented magnitude and changed our perspective on this lethal but sporadically emerging virus. This outbreak also marked the beginning of large-scale real-time molecular epidemiology. Here, we show how evolutionary analyses of Ebola virus genome sequences provided key insights into virus origins, evolution and spread during the epidemic. We provide basic scientists, epidemiologists, medical practitioners and other outbreak responders with an enhanced understanding of the utility and limitations of pathogen genomic sequencing. This will be crucially important in our attempts to track and control future infectious disease outbreaks.

Date: 2016
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DOI: 10.1038/nature19790

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