Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

Alexandra East-Seletsky, Mitchell R. O’Connell, Spencer C. Knight, David Burstein, Jamie H. D. Cate, Robert Tjian and Jennifer A. Doudna ()
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Alexandra East-Seletsky: University of California
Mitchell R. O’Connell: University of California
Spencer C. Knight: University of California
David Burstein: University of California
Jamie H. D. Cate: University of California
Robert Tjian: University of California
Jennifer A. Doudna: University of California

Nature, 2016, vol. 538, issue 7624, 270-273

Abstract: The CRISPR-associated bacterial enzyme C2c2 is shown to contain two separable, distinct sites for the highly sensitive detection and cleavage of single-stranded RNA.

Date: 2016
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DOI: 10.1038/nature19802

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