Genome-wide associations for birth weight and correlations with adult disease

Momoko Horikoshi, Robin N. Beaumont, Felix R. Day, Nicole M. Warrington, Marjolein N. Kooijman, Juan Fernandez-Tajes, Bjarke Feenstra, Natalie R. van Zuydam, Kyle J. Gaulton, Niels Grarup, Jonathan P. Bradfield, David P. Strachan, Ruifang Li-Gao, Tarunveer S. Ahluwalia, Eskil Kreiner, Rico Rueedi, Leo-Pekka Lyytikäinen, Diana L. Cousminer, Ying Wu, Elisabeth Thiering, Carol A. Wang, Christian T. Have, Jouke-Jan Hottenga, Natalia Vilor-Tejedor, Peter K. Joshi, Eileen Tai Hui Boh, Ioanna Ntalla, Niina Pitkänen, Anubha Mahajan, Elisabeth M. van Leeuwen, Raimo Joro, Vasiliki Lagou, Michael Nodzenski, Louise A. Diver, Krina T. Zondervan, Mariona Bustamante, Pedro Marques-Vidal, Josep M. Mercader, Amanda J. Bennett, Nilufer Rahmioglu, Dale R. Nyholt, Ronald C. W. Ma, Claudia H. T. Tam, Wing Hung Tam, Santhi K. Ganesh, Frank J. A. van Rooij, Samuel E. Jones, Po-Ru Loh, Katherine S. Ruth, Marcus A. Tuke, Jessica Tyrrell, Andrew R. Wood, Hanieh Yaghootkar, Denise M. Scholtens, Lavinia Paternoster, Inga Prokopenko, Peter Kovacs, Mustafa Atalay, Sara M. Willems, Kalliope Panoutsopoulou, Xu Wang, Lisbeth Carstensen, Frank Geller, Katharina E. Schraut, Mario Murcia, Catharina E. M. van Beijsterveldt, Gonneke Willemsen, Emil V. R. Appel, Cilius E. Fonvig, Caecilie Trier, Carla M. T. Tiesler, Marie Standl, Zoltán Kutalik, Sílvia Bonàs-Guarch, David M. Hougaard, Friman Sánchez, David Torrents, Johannes Waage, Mads V. Hollegaard, Hugoline G. de Haan, Frits R. Rosendaal, Carolina Medina-Gomez, Susan M. Ring, Gibran Hemani, George McMahon, Neil R. Robertson, Christopher J. Groves, Claudia Langenberg, Jian’an Luan, Robert A. Scott, Jing Hua Zhao, Frank D. Mentch, Scott M. MacKenzie, Rebecca M. Reynolds, William L. Lowe, Anke Tönjes, Michael Stumvoll, Virpi Lindi, Timo A. Lakka, Cornelia M. van Duijn, Wieland Kiess, Antje Körner, Thorkild I. A. Sørensen, Harri Niinikoski, Katja Pahkala, Olli T. Raitakari, Eleftheria Zeggini, George V. Dedoussis, Yik-Ying Teo, Seang-Mei Saw, Mads Melbye, Harry Campbell, James F. Wilson, Martine Vrijheid, Eco J. C. N. de Geus, Dorret I. Boomsma, Haja N. Kadarmideen, Jens-Christian Holm, Torben Hansen, Sylvain Sebert, Andrew T. Hattersley, Lawrence J. Beilin, John P. Newnham, Craig E. Pennell, Joachim Heinrich, Linda S. Adair, Judith B. Borja, Karen L. Mohlke, Johan G. Eriksson, Elisabeth Widén, Mika Kähönen, Jorma S. Viikari, Terho Lehtimäki, Peter Vollenweider, Klaus Bønnelykke, Hans Bisgaard, Dennis O. Mook-Kanamori, Albert Hofman, Fernando Rivadeneira, André G. Uitterlinden, Charlotta Pisinger, Oluf Pedersen, Christine Power, Elina Hyppönen, Nicholas J. Wareham, Hakon Hakonarson, Eleanor Davies, Brian R. Walker, Vincent W. V. Jaddoe, Marjo-Riitta Järvelin, Struan F. A. Grant, Allan A. Vaag, Debbie A. Lawlor, Timothy M. Frayling, George Davey Smith, Andrew P. Morris, Ken K. Ong, Janine F. Felix, Nicholas J. Timpson, John R. B. Perry, David M. Evans, Mark I. McCarthy () and Rachel M. Freathy ()
Additional contact information
Momoko Horikoshi: Wellcome Trust Centre for Human Genetics, University of Oxford
Robin N. Beaumont: Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital
Felix R. Day: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Nicole M. Warrington: The University of Queensland Diamantina Institute, Translational Research Institute
Marjolein N. Kooijman: The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
Juan Fernandez-Tajes: Wellcome Trust Centre for Human Genetics, University of Oxford
Bjarke Feenstra: Statens Serum Institut
Natalie R. van Zuydam: Wellcome Trust Centre for Human Genetics, University of Oxford
Kyle J. Gaulton: Wellcome Trust Centre for Human Genetics, University of Oxford
Niels Grarup: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Jonathan P. Bradfield: Center for Applied Genomics, The Children’s Hospital of Philadelphia
David P. Strachan: Population Health Research Institute, St George’s University of London, Cranmer
Ruifang Li-Gao: Leiden University Medical Center
Tarunveer S. Ahluwalia: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Eskil Kreiner: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
Rico Rueedi: University of Lausanne
Leo-Pekka Lyytikäinen: Fimlab Laboratories
Diana L. Cousminer: Institute for Molecular Medicine, Finland (FIMM), University of Helsinki
Ying Wu: University of North Carolina
Elisabeth Thiering: Institute of Epidemiology I, Helmholtz Zentrum München- German Research Center for Environmental Health
Carol A. Wang: School of Women’s and Infants’ Health, The University of Western Australia
Christian T. Have: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Jouke-Jan Hottenga: Netherlands Twin Register, Vrije Universiteit
Natalia Vilor-Tejedor: ISGlobal, Centre for Research in Environmental Epidemiology (CREAL)
Peter K. Joshi: Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
Eileen Tai Hui Boh: Saw Swee Hock School of Public Health, National University of Singapore, National University Health System
Ioanna Ntalla: William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
Niina Pitkänen: Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
Anubha Mahajan: Wellcome Trust Centre for Human Genetics, University of Oxford
Elisabeth M. van Leeuwen: Erasmus MC, University Medical Center Rotterdam
Raimo Joro: Institute of Biomedicine, Physiology, University of Eastern Finland
Vasiliki Lagou: Wellcome Trust Centre for Human Genetics, University of Oxford
Michael Nodzenski: Feinberg School of Medicine, Northwestern University
Louise A. Diver: Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
Krina T. Zondervan: Wellcome Trust Centre for Human Genetics, University of Oxford
Mariona Bustamante: ISGlobal, Centre for Research in Environmental Epidemiology (CREAL)
Pedro Marques-Vidal: Internal Medicine, Lausanne University Hospital (CHUV)
Josep M. Mercader: Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center
Amanda J. Bennett: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
Nilufer Rahmioglu: Wellcome Trust Centre for Human Genetics, University of Oxford
Dale R. Nyholt: Institute of Health and Biomedical Innovation, Queensland University of Technology
Ronald C. W. Ma: The Chinese University of Hong Kong
Claudia H. T. Tam: The Chinese University of Hong Kong
Wing Hung Tam: The Chinese University of Hong Kong
Santhi K. Ganesh: University of Michigan
Frank J. A. van Rooij: Erasmus MC, University Medical Center Rotterdam
Samuel E. Jones: Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital
Po-Ru Loh: Harvard T.H. Chan School of Public Health
Katherine S. Ruth: Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital
Marcus A. Tuke: Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital
Jessica Tyrrell: Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital
Andrew R. Wood: Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital
Hanieh Yaghootkar: Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital
Denise M. Scholtens: Feinberg School of Medicine, Northwestern University
Lavinia Paternoster: Medical Research Council Integrative Epidemiology Unit at the University of Bristol
Inga Prokopenko: Wellcome Trust Centre for Human Genetics, University of Oxford
Peter Kovacs: IFB Adiposity Diseases, University of Leipzig
Mustafa Atalay: Institute of Biomedicine, Physiology, University of Eastern Finland
Sara M. Willems: Erasmus MC, University Medical Center Rotterdam
Kalliope Panoutsopoulou: Wellcome Trust Sanger Institute, Hinxton
Xu Wang: Saw Swee Hock School of Public Health, National University of Singapore, National University Health System
Lisbeth Carstensen: Statens Serum Institut
Frank Geller: Statens Serum Institut
Katharina E. Schraut: Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
Mario Murcia: CIBER de Epidemiología y Salud Pública (CIBERESP)
Catharina E. M. van Beijsterveldt: Netherlands Twin Register, Vrije Universiteit
Gonneke Willemsen: Netherlands Twin Register, Vrije Universiteit
Emil V. R. Appel: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Cilius E. Fonvig: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Caecilie Trier: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Carla M. T. Tiesler: Institute of Epidemiology I, Helmholtz Zentrum München- German Research Center for Environmental Health
Marie Standl: Institute of Epidemiology I, Helmholtz Zentrum München- German Research Center for Environmental Health
Zoltán Kutalik: Swiss Institute of Bioinformatics
Sílvia Bonàs-Guarch: Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center
David M. Hougaard: Danish Center for Neonatal Screening, Statens Serum Institute
Friman Sánchez: Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center
David Torrents: Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center
Johannes Waage: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
Mads V. Hollegaard: Danish Center for Neonatal Screening, Statens Serum Institute
Hugoline G. de Haan: Leiden University Medical Center
Frits R. Rosendaal: Leiden University Medical Center
Carolina Medina-Gomez: The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
Susan M. Ring: Medical Research Council Integrative Epidemiology Unit at the University of Bristol
Gibran Hemani: Medical Research Council Integrative Epidemiology Unit at the University of Bristol
George McMahon: School of Social and Community Medicine, University of Bristol
Neil R. Robertson: Wellcome Trust Centre for Human Genetics, University of Oxford
Christopher J. Groves: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
Claudia Langenberg: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Jian’an Luan: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Robert A. Scott: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Jing Hua Zhao: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Frank D. Mentch: Center for Applied Genomics, The Children’s Hospital of Philadelphia
Scott M. MacKenzie: Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
Rebecca M. Reynolds: BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute
William L. Lowe: Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University
Anke Tönjes: University of Leipzig
Michael Stumvoll: IFB Adiposity Diseases, University of Leipzig
Virpi Lindi: Institute of Biomedicine, Physiology, University of Eastern Finland
Timo A. Lakka: Institute of Biomedicine, Physiology, University of Eastern Finland
Cornelia M. van Duijn: Erasmus MC, University Medical Center Rotterdam
Wieland Kiess: Pediatric Research Center, University of Leipzig
Antje Körner: IFB Adiposity Diseases, University of Leipzig
Thorkild I. A. Sørensen: Medical Research Council Integrative Epidemiology Unit at the University of Bristol
Harri Niinikoski: Turku University Hospital
Katja Pahkala: Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
Olli T. Raitakari: Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
Eleftheria Zeggini: Wellcome Trust Sanger Institute, Hinxton
George V. Dedoussis: School of Health Science and Education, Harokopio University
Yik-Ying Teo: Saw Swee Hock School of Public Health, National University of Singapore, National University Health System
Seang-Mei Saw: Saw Swee Hock School of Public Health, National University of Singapore, National University Health System
Mads Melbye: Statens Serum Institut
Harry Campbell: Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
James F. Wilson: Usher Institute for Population Health Sciences and Informatics, University of Edinburgh
Martine Vrijheid: ISGlobal, Centre for Research in Environmental Epidemiology (CREAL)
Eco J. C. N. de Geus: Netherlands Twin Register, Vrije Universiteit
Dorret I. Boomsma: Netherlands Twin Register, Vrije Universiteit
Haja N. Kadarmideen: Faculty of Health and Medical Sciences, University of Copenhagen
Jens-Christian Holm: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Torben Hansen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Sylvain Sebert: School of Public Health, Imperial College London
Andrew T. Hattersley: Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital
Lawrence J. Beilin: School of Medicine and Pharmacology, Royal Perth Hospital Unit, The University of Western Australia
John P. Newnham: School of Women’s and Infants’ Health, The University of Western Australia
Craig E. Pennell: School of Women’s and Infants’ Health, The University of Western Australia
Joachim Heinrich: Institute of Epidemiology I, Helmholtz Zentrum München- German Research Center for Environmental Health
Linda S. Adair: University of North Carolina
Judith B. Borja: USC-Office of Population Studies Foundation, Inc., University of San Carlos
Karen L. Mohlke: University of North Carolina
Johan G. Eriksson: National Institute for Health and Welfare
Elisabeth Widén: Institute for Molecular Medicine, Finland (FIMM), University of Helsinki
Mika Kähönen: Tampere University Hopital
Jorma S. Viikari: Turku University Hospital
Terho Lehtimäki: Fimlab Laboratories
Peter Vollenweider: Internal Medicine, Lausanne University Hospital (CHUV)
Klaus Bønnelykke: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
Hans Bisgaard: COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen
Dennis O. Mook-Kanamori: Leiden University Medical Center
Albert Hofman: The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
Fernando Rivadeneira: The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
André G. Uitterlinden: The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
Charlotta Pisinger: Research Center for Prevention and Health Capital Region, Center for Sundhed, Rigshospitalet – Glostrup, Copenhagen University
Oluf Pedersen: The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
Christine Power: Population, Policy and Practice, UCL Institute of Child Health, University College London
Elina Hyppönen: Population, Policy and Practice, UCL Institute of Child Health, University College London
Nicholas J. Wareham: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Hakon Hakonarson: Center for Applied Genomics, The Children’s Hospital of Philadelphia
Eleanor Davies: Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
Brian R. Walker: BHF Centre for Cardiovascular Science, University of Edinburgh, Queen’s Medical Research Institute
Vincent W. V. Jaddoe: The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
Marjo-Riitta Järvelin: Center for Life Course Health Research, Faculty of Medicine, University of Oulu
Struan F. A. Grant: Center for Applied Genomics, The Children’s Hospital of Philadelphia
Allan A. Vaag: University of Copenhagen
Debbie A. Lawlor: Medical Research Council Integrative Epidemiology Unit at the University of Bristol
Timothy M. Frayling: Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital
George Davey Smith: Medical Research Council Integrative Epidemiology Unit at the University of Bristol
Andrew P. Morris: Wellcome Trust Centre for Human Genetics, University of Oxford
Ken K. Ong: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
Janine F. Felix: The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam
Nicholas J. Timpson: Medical Research Council Integrative Epidemiology Unit at the University of Bristol
John R. B. Perry: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
David M. Evans: The University of Queensland Diamantina Institute, Translational Research Institute
Mark I. McCarthy: Wellcome Trust Centre for Human Genetics, University of Oxford
Rachel M. Freathy: Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital

Nature, 2016, vol. 538, issue 7624, 248-252

Abstract: Multi-ancestry genome-wide association analyses for birth weight in 153,781 individuals identified 60 genomic loci in which birth weight and fetal genotype were associated and found an inverse genetic correlation between birth weight and cardiometabolic risk.

Date: 2016
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DOI: 10.1038/nature19806

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