X-ray structure of the human α4β2 nicotinic receptor

Claudio L. Morales-Perez, Colleen M. Noviello and Ryan E. Hibbs ()
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Claudio L. Morales-Perez: University of Texas Southwestern Medical Center
Colleen M. Noviello: University of Texas Southwestern Medical Center
Ryan E. Hibbs: University of Texas Southwestern Medical Center

Nature, 2016, vol. 538, issue 7625, 411-415

Abstract: Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical neurotransmission; here, the first X-ray crystal structure of a nicotinic receptor is reported, revealing how nicotine stabilizes the receptor in a non-conducting, desensitized conformation.

Date: 2016
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DOI: 10.1038/nature19785

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