The epichaperome is an integrated chaperome network that facilitates tumour survival

Anna Rodina, Tai Wang, Pengrong Yan, Erica DaGama Gomes, Mark P. S. Dunphy, Nagavarakishore Pillarsetty, John Koren, John F. Gerecitano, Tony Taldone, Hongliang Zong, Eloisi Caldas-Lopes, Mary Alpaugh, Adriana Corben, Matthew Riolo, Brad Beattie, Christina Pressl, Radu I. Peter, Chao Xu, Robert Trondl, Hardik J. Patel, Fumiko Shimizu, Alexander Bolaender, Chenghua Yang, Palak Panchal, Mohammad F. Farooq, Sarah Kishinevsky, Shanu Modi, Oscar Lin, Feixia Chu, Sujata Patil, Hediye Erdjument-Bromage, Pat Zanzonico, Clifford Hudis, Lorenz Studer, Gail J. Roboz, Ethel Cesarman, Leandro Cerchietti, Ross Levine, Ari Melnick, Steven M. Larson, Jason S. Lewis, Monica L. Guzman () and Gabriela Chiosis ()
Additional contact information
Anna Rodina: Program in Chemical Biology, Sloan Kettering Institute
Tai Wang: Program in Chemical Biology, Sloan Kettering Institute
Pengrong Yan: Program in Chemical Biology, Sloan Kettering Institute
Erica DaGama Gomes: Program in Chemical Biology, Sloan Kettering Institute
Mark P. S. Dunphy: Memorial Sloan Kettering Cancer Center
Nagavarakishore Pillarsetty: Memorial Sloan Kettering Cancer Center
John Koren: Program in Chemical Biology, Sloan Kettering Institute
John F. Gerecitano: Lymphoma Service, Memorial Sloan Kettering Cancer Center
Tony Taldone: Program in Chemical Biology, Sloan Kettering Institute
Hongliang Zong: Haematology and Medical Oncology, Weill Cornell Medical College
Eloisi Caldas-Lopes: Program in Chemical Biology, Sloan Kettering Institute
Mary Alpaugh: Program in Chemical Biology, Sloan Kettering Institute
Adriana Corben: Memorial Sloan Kettering Cancer Center
Matthew Riolo: Program in Chemical Biology, Sloan Kettering Institute
Brad Beattie: Memorial Sloan Kettering Cancer Center
Christina Pressl: Memorial Sloan Kettering Cancer Center
Radu I. Peter: Technical University of Cluj-Napoca
Chao Xu: Program in Chemical Biology, Sloan Kettering Institute
Robert Trondl: Program in Chemical Biology, Sloan Kettering Institute
Hardik J. Patel: Program in Chemical Biology, Sloan Kettering Institute
Fumiko Shimizu: Program in Chemical Biology, Sloan Kettering Institute
Alexander Bolaender: Program in Chemical Biology, Sloan Kettering Institute
Chenghua Yang: Program in Chemical Biology, Sloan Kettering Institute
Palak Panchal: Program in Chemical Biology, Sloan Kettering Institute
Mohammad F. Farooq: Molecular, Cellular & Biomedical Sciences, University of New Hampshire
Sarah Kishinevsky: Program in Chemical Biology, Sloan Kettering Institute
Shanu Modi: Breast Cancer Service, Memorial Sloan Kettering Cancer Center
Oscar Lin: Memorial Sloan Kettering Cancer Center
Feixia Chu: Molecular, Cellular & Biomedical Sciences, University of New Hampshire
Sujata Patil: Memorial Sloan Kettering Cancer Center
Hediye Erdjument-Bromage: Microchemistry and Proteomics Core, Molecular Biology Program, Memorial Sloan Kettering Cancer Center
Pat Zanzonico: Memorial Sloan Kettering Cancer Center
Clifford Hudis: Breast Cancer Service, Memorial Sloan Kettering Cancer Center
Lorenz Studer: Developmental Biology Program, Memorial Sloan Kettering Cancer Center
Gail J. Roboz: Haematology and Medical Oncology, Weill Cornell Medical College
Ethel Cesarman: Haematology and Medical Oncology, Weill Cornell Medical College
Leandro Cerchietti: Haematology and Medical Oncology, Weill Cornell Medical College
Ross Levine: Human Oncology and Pathogenesis Program, Sloan Kettering Institute
Ari Melnick: Haematology and Medical Oncology, Weill Cornell Medical College
Steven M. Larson: Memorial Sloan Kettering Cancer Center
Jason S. Lewis: Memorial Sloan Kettering Cancer Center
Monica L. Guzman: Haematology and Medical Oncology, Weill Cornell Medical College
Gabriela Chiosis: Program in Chemical Biology, Sloan Kettering Institute

Nature, 2016, vol. 538, issue 7625, 397-401

Abstract: Chaperomes are dynamic assemblies of proteins that regulate cellular homeostasis but specific cellular stresses remodel chaperome components into a stable chaperome network called the epichaperome, which might offer a new cancer target.

Date: 2016
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DOI: 10.1038/nature19807

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