Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts

Yuji Shiba (), Toshihito Gomibuchi, Tatsuichiro Seto, Yuko Wada, Hajime Ichimura, Yuki Tanaka, Tatsuki Ogasawara, Kenji Okada, Naoko Shiba, Kengo Sakamoto, Daisuke Ido, Takashi Shiina, Masamichi Ohkura, Junichi Nakai, Narumi Uno, Yasuhiro Kazuki, Mitsuo Oshimura, Itsunari Minami and Uichi Ikeda
Additional contact information
Yuji Shiba: Institute for Biomedical Sciences, Shinshu University
Toshihito Gomibuchi: Shinshu University School of Medicine
Tatsuichiro Seto: Shinshu University School of Medicine
Yuko Wada: Shinshu University School of Medicine
Hajime Ichimura: Shinshu University School of Medicine
Yuki Tanaka: Shinshu University School of Medicine
Tatsuki Ogasawara: Shinshu University School of Medicine
Kenji Okada: Shinshu University School of Medicine
Naoko Shiba: Shinshu University School of Medicine
Kengo Sakamoto: Ina Research Inc.
Daisuke Ido: Ina Research Inc.
Takashi Shiina: Tokai University School of Medicine
Masamichi Ohkura: Brain Science Institute, Saitama University
Junichi Nakai: Brain Science Institute, Saitama University
Narumi Uno: Chromosome Engineering Research Center, Tottori University
Yasuhiro Kazuki: Chromosome Engineering Research Center, Tottori University
Mitsuo Oshimura: Chromosome Engineering Research Center, Tottori University
Itsunari Minami: Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University
Uichi Ikeda: Shinshu University School of Medicine

Nature, 2016, vol. 538, issue 7625, 388-391

Abstract: Allogenic induced pluripotent stem cell-derived cardiomyocytes transplanted directly into infarcted cynomolgus monkey hearts show electrical coupling with host cardiomyocytes improve cardiac contractile function after mild immunosuppression.

Date: 2016
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DOI: 10.1038/nature19815

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