A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

Faiyaz Notta (), Michelle Chan-Seng-Yue, Mathieu Lemire, Yilong Li, Gavin W. Wilson, Ashton A. Connor, Robert E. Denroche, Sheng-Ben Liang, Andrew M. K. Brown, Jaeseung C. Kim, Tao Wang, Jared T. Simpson, Timothy Beck, Ayelet Borgida, Nicholas Buchner, Dianne Chadwick, Sara Hafezi-Bakhtiari, John E. Dick, Lawrence Heisler, Michael A. Hollingsworth, Emin Ibrahimov, Gun Ho Jang, Jeremy Johns, Lars G. T. Jorgensen, Calvin Law, Olga Ludkovski, Ilinca Lungu, Karen Ng, Danielle Pasternack, Gloria M. Petersen, Liran I. Shlush, Lee Timms, Ming-Sound Tsao, Julie M. Wilson, Christina K. Yung, George Zogopoulos, John M. S. Bartlett, Ludmil B. Alexandrov, Francisco X. Real, Sean P. Cleary, Michael H. Roehrl, John D. McPherson, Lincoln D. Stein, Thomas J. Hudson (), Peter J. Campbell and Steven Gallinger
Additional contact information
Faiyaz Notta: Ontario Institute for Cancer Research
Michelle Chan-Seng-Yue: Ontario Institute for Cancer Research
Mathieu Lemire: Ontario Institute for Cancer Research
Yilong Li: Cancer Genome Project, Wellcome Trust Sanger Institute
Gavin W. Wilson: Ontario Institute for Cancer Research
Ashton A. Connor: Ontario Institute for Cancer Research
Robert E. Denroche: Ontario Institute for Cancer Research
Sheng-Ben Liang: UHN Program in BioSpecimen Sciences, University Health Network
Andrew M. K. Brown: Ontario Institute for Cancer Research
Jaeseung C. Kim: Ontario Institute for Cancer Research
Tao Wang: University of Toronto
Jared T. Simpson: Ontario Institute for Cancer Research
Timothy Beck: Ontario Institute for Cancer Research
Ayelet Borgida: Eppley Institute for Research in Cancer, Nebraska Medical Center
Nicholas Buchner: Ontario Institute for Cancer Research
Dianne Chadwick: UHN Program in BioSpecimen Sciences, University Health Network
Sara Hafezi-Bakhtiari: Ontario Institute for Cancer Research
John E. Dick: Ontario Institute for Cancer Research
Lawrence Heisler: Ontario Institute for Cancer Research
Michael A. Hollingsworth: Eppley Institute for Research in Cancer, Nebraska Medical Center
Emin Ibrahimov: Ontario Institute for Cancer Research
Gun Ho Jang: Ontario Institute for Cancer Research
Jeremy Johns: Ontario Institute for Cancer Research
Lars G. T. Jorgensen: Ontario Institute for Cancer Research
Calvin Law: Sunnybrook Health Sciences Centre, Odette Cancer Centre
Olga Ludkovski: Princess Margaret Cancer Centre, University Health Network (UHN)
Ilinca Lungu: Ontario Institute for Cancer Research
Karen Ng: Ontario Institute for Cancer Research
Danielle Pasternack: Ontario Institute for Cancer Research
Gloria M. Petersen: Mayo Clinic
Liran I. Shlush: Princess Margaret Cancer Centre, University Health Network (UHN)
Lee Timms: Ontario Institute for Cancer Research
Ming-Sound Tsao: University of Toronto
Julie M. Wilson: Ontario Institute for Cancer Research
Christina K. Yung: Ontario Institute for Cancer Research
George Zogopoulos: Research Institute of the McGill University Health Centre, Montreal
John M. S. Bartlett: Ontario Institute for Cancer Research
Ludmil B. Alexandrov: Theoretical Biology and Biophysics (T-6) and Center for Nonlinear Studies, Los Alamos National Laboratory
Francisco X. Real: Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO)
Sean P. Cleary: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Michael H. Roehrl: UHN Program in BioSpecimen Sciences, University Health Network
John D. McPherson: Ontario Institute for Cancer Research
Lincoln D. Stein: Ontario Institute for Cancer Research
Thomas J. Hudson: Ontario Institute for Cancer Research
Peter J. Campbell: Cancer Genome Project, Wellcome Trust Sanger Institute
Steven Gallinger: Ontario Institute for Cancer Research

Nature, 2016, vol. 538, issue 7625, 378-382

Abstract: Pancreatic cancer is not caused by a specific series of genetic alterations that occur sequentially but by one, or few, catastrophic events that result in simultaneous oncogenic genetic rearrangements, giving rise to highly aggressive tumours.

Date: 2016
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DOI: 10.1038/nature19823

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