T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments

Edwin D. Hawkins (), Delfim Duarte, Olufolake Akinduro, Reema A. Khorshed, Diana Passaro, Malgorzata Nowicka, Lenny Straszkowski, Mark K. Scott, Steve Rothery, Nicola Ruivo, Katie Foster, Michaela Waibel, Ricky W. Johnstone, Simon J. Harrison, David A. Westerman, Hang Quach, John Gribben, Mark D. Robinson, Louise E. Purton, Dominique Bonnet and Cristina Lo Celso ()
Additional contact information
Edwin D. Hawkins: Sir Alexander Fleming Building, Imperial College London
Delfim Duarte: Sir Alexander Fleming Building, Imperial College London
Olufolake Akinduro: Sir Alexander Fleming Building, Imperial College London
Reema A. Khorshed: Sir Alexander Fleming Building, Imperial College London
Diana Passaro: The Francis Crick Institute, Haematopoietic Stem Cell Laboratory
Malgorzata Nowicka: SIB Swiss Institute of Bioinformatics and Institute of Molecular Life Sciences, University of Zurich
Lenny Straszkowski: Stem Cell Regulation Unit, St Vincent’s Institute of Medical Research
Mark K. Scott: Sir Alexander Fleming Building, Imperial College London
Steve Rothery: Imperial College Facility for Imaging by Light Microscopy, Sir Alexander Fleming Building, Imperial College London
Nicola Ruivo: Sir Alexander Fleming Building, Imperial College London
Katie Foster: The Francis Crick Institute, Haematopoietic Stem Cell Laboratory
Michaela Waibel: University of Melbourne
Ricky W. Johnstone: University of Melbourne
Simon J. Harrison: University of Melbourne
David A. Westerman: University of Melbourne
Hang Quach: St Vincent’s Hospital
John Gribben: Centre of Haemato-Oncology, Cancer Research UK Clinical Centre, Barts Cancer Institute, St Bartholomew’s Hospital, Queen Mary University of London
Mark D. Robinson: SIB Swiss Institute of Bioinformatics and Institute of Molecular Life Sciences, University of Zurich
Louise E. Purton: Stem Cell Regulation Unit, St Vincent’s Institute of Medical Research
Dominique Bonnet: The Francis Crick Institute, Haematopoietic Stem Cell Laboratory
Cristina Lo Celso: Sir Alexander Fleming Building, Imperial College London

Nature, 2016, vol. 538, issue 7626, 518-522

Abstract: Here, leukaemia cells are followed by intravital microscopy as they infiltrate mouse bone marrow and respond to chemotherapy, revealing that at all stages analysed they are highly motile and do not display any associations with particular bone marrow sub-compartments.

Date: 2016
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DOI: 10.1038/nature19801

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