Synchronous long-term oscillations in a synthetic gene circuit

Laurent Potvin-Trottier, Nathan D. Lord, Glenn Vinnicombe and Johan Paulsson ()
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Laurent Potvin-Trottier: Harvard Medical School
Nathan D. Lord: Harvard Medical School
Glenn Vinnicombe: University of Cambridge
Johan Paulsson: Harvard Medical School

Nature, 2016, vol. 538, issue 7626, 514-517

Abstract: The first synthetic genetic oscillator or ‘repressilator’ is simplified using insights from stochastic theory, thus achieving remarkably precise and robust oscillations and informing current debates about the next generation of synthetic circuits and their potential applications in cell-based therapies.

Date: 2016
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DOI: 10.1038/nature19841

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