TET-mediated DNA demethylation controls gastrulation by regulating Lefty–Nodal signalling

Hai-Qiang Dai, Bang-An Wang, Lu Yang, Jia-Jia Chen, Guo-Chun Zhu, Mei-Ling Sun, Hao Ge, Rui Wang, Deborah L. Chapman, Fuchou Tang, Xin Sun () and Guo-Liang Xu ()
Additional contact information
Hai-Qiang Dai: State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Bang-An Wang: State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Lu Yang: Biodynamic Optical Imaging Center, College of Life Sciences, Peking University
Jia-Jia Chen: State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Guo-Chun Zhu: State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Mei-Ling Sun: School of Life Science and Technology, ShanghaiTech University
Hao Ge: Biodynamic Optical Imaging Center, College of Life Sciences, Peking University
Rui Wang: Biodynamic Optical Imaging Center, College of Life Sciences, Peking University
Deborah L. Chapman: University of Pittsburgh
Fuchou Tang: Biodynamic Optical Imaging Center, College of Life Sciences, Peking University
Xin Sun: Laboratory of Genetics, University of Wisconsin-Madison
Guo-Liang Xu: State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

Nature, 2016, vol. 538, issue 7626, 528-532

Abstract: Inactivation of three Tet genes in mice leads to gastrulation phenotypes similar to those in embryos with increased Nodal signalling, revealing a functional redundancy of Tet genes and showing balanced and dynamic DNA methylation and demethylation is crucial to regulate key signalling pathways in early body plan formation.

Date: 2016
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DOI: 10.1038/nature20095

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