On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

Hyejin Cho, Xinlin Du, James P. Rizzi, Ella Liberzon, Abhishek A. Chakraborty, Wenhua Gao, Ingrid Carvo, Sabina Signoretti, Richard K. Bruick, John A. Josey, Eli M. Wallace () and William G. Kaelin ()
Additional contact information
Hyejin Cho: Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School
Xinlin Du: Peloton Therapeutics, Inc.
James P. Rizzi: Peloton Therapeutics, Inc.
Ella Liberzon: Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School
Abhishek A. Chakraborty: Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School
Wenhua Gao: Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School
Ingrid Carvo: Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School
Sabina Signoretti: Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School
Richard K. Bruick: University of Texas Southwestern Medical Center
John A. Josey: Peloton Therapeutics, Inc.
Eli M. Wallace: Peloton Therapeutics, Inc.
William G. Kaelin: Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School

Nature, 2016, vol. 539, issue 7627, 107-111

Abstract: The small-molecule HIF-2α antagonist PT2399 causes tumour regression in animal models of clear cell renal cell carcinoma, but cell lines of this tumour type show unexpectedly variable responses to PT2399.

Date: 2016
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DOI: 10.1038/nature19795

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