Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway

Yong Yu, Jason C. H. Tsang, Cui Wang, Simon Clare, Juexuan Wang, Xi Chen, Cordelia Brandt, Leanne Kane, Lia S. Campos, Liming Lu, Gabrielle T. Belz, Andrew N. J. McKenzie, Sarah A. Teichmann, Gordon Dougan and Pentao Liu ()
Additional contact information
Yong Yu: Wellcome Trust Sanger Institute
Jason C. H. Tsang: Wellcome Trust Sanger Institute
Cui Wang: Wellcome Trust Sanger Institute
Simon Clare: Wellcome Trust Sanger Institute
Juexuan Wang: Wellcome Trust Sanger Institute
Xi Chen: Wellcome Trust Sanger Institute
Cordelia Brandt: Wellcome Trust Sanger Institute
Leanne Kane: Wellcome Trust Sanger Institute
Lia S. Campos: Wellcome Trust Sanger Institute
Liming Lu: Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine
Gabrielle T. Belz: The Walter and Eliza Hall Institute of Medical Research, Parkville
Andrew N. J. McKenzie: Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus
Sarah A. Teichmann: Wellcome Trust Sanger Institute
Gordon Dougan: Wellcome Trust Sanger Institute
Pentao Liu: Wellcome Trust Sanger Institute

Nature, 2016, vol. 539, issue 7627, 102-106

Abstract: Single-cell RNA sequencing of bone marrow innate lymphoid cell (ILC) precursors reveals that PD-1 marks a committed ILC progenitor and that ILC2 development requires Bcl11b and IL-25R expression; activated ILCs can also be depleted by a PD-1 antibody.

Date: 2016
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DOI: 10.1038/nature20105

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