Reconstitution in vitro of the entire cycle of the mouse female germ line

Orie Hikabe, Nobuhiko Hamazaki, Go Nagamatsu, Yayoi Obata, Yuji Hirao, Norio Hamada, So Shimamoto, Takuya Imamura, Kinichi Nakashima, Mitinori Saitou and Katsuhiko Hayashi ()
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Orie Hikabe: Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1
Nobuhiko Hamazaki: Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1
Go Nagamatsu: Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1
Yayoi Obata: Tokyo University of Agriculture, 1-1-1, Sakuragaoka
Yuji Hirao: NARO Institute of Livestock and Grassland Science
Norio Hamada: Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1
So Shimamoto: Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1
Takuya Imamura: Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1
Kinichi Nakashima: Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1
Mitinori Saitou: Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho
Katsuhiko Hayashi: Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1

Nature, 2016, vol. 539, issue 7628, 299-303

Abstract: Using a protocol that recapitulates both meiosis and oocyte growth in vitro, the authors induce mouse pluripotent stem cells to differentiate into fully functional oocytes that can be fertilized and generate viable offspring, thereby recapitulating the full mammalian female germline cycle in a dish.

Date: 2016
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DOI: 10.1038/nature20104

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