Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

Xiaochao Wei, Haowei Song, Li Yin, Michael G. Rizzo, Rohini Sidhu, Douglas F. Covey, Daniel S. Ory and Clay F. Semenkovich ()
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Xiaochao Wei: Metabolism and Lipid Research, Washington University School of Medicine
Haowei Song: Metabolism and Lipid Research, Washington University School of Medicine
Li Yin: Metabolism and Lipid Research, Washington University School of Medicine
Michael G. Rizzo: Metabolism and Lipid Research, Washington University School of Medicine
Rohini Sidhu: Diabetic Cardiovascular Disease Center, Washington University School of Medicine
Douglas F. Covey: Washington University School of Medicine
Daniel S. Ory: Diabetic Cardiovascular Disease Center, Washington University School of Medicine
Clay F. Semenkovich: Metabolism and Lipid Research, Washington University School of Medicine

Nature, 2016, vol. 539, issue 7628, 294-298

Abstract: Mice with macrophages deficient in fatty acid synthase exhibit lower levels of diabetes-related insulin resistance and inflammation, qualities that are restored on addition of exogenous cholesterol.

Date: 2016
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DOI: 10.1038/nature20117

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