Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

Lei Dong, Wen-Mei Yu, Hong Zheng, Mignon L. Loh, Silvia T. Bunting, Melinda Pauly, Gang Huang, Muxiang Zhou, Hal E. Broxmeyer, David T. Scadden and Cheng-Kui Qu ()
Additional contact information
Lei Dong: Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine
Wen-Mei Yu: Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine
Hong Zheng: Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine
Mignon L. Loh: University of California at San Francisco, San Francisco
Silvia T. Bunting: Children’s Healthcare of Atlanta, Emory University
Melinda Pauly: Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine
Gang Huang: Cincinnati Children's Hospital, University of Cincinnati
Muxiang Zhou: Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine
Hal E. Broxmeyer: Indiana University School of Medicine
David T. Scadden: Center for Regenerative Medicine and MGH Cancer Center, Massachusetts General Hospital, Harvard University
Cheng-Kui Qu: Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine

Nature, 2016, vol. 539, issue 7628, 304-308

Abstract: Mutations in the protein tyrosine phosphatase SHP2 affect cells in the bone marrow environment, which leads to aberrant activation of resident haematopoietic stem cells and thereby contributes to the development of leukaemia.

Date: 2016
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DOI: 10.1038/nature20131

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