The road to restoring neural circuits for the treatment of Alzheimer's disease

Rebecca G. Canter, Jay Penney and Li-Huei Tsai ()
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Rebecca G. Canter: The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Jay Penney: The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Li-Huei Tsai: The Picower Institute for Learning and Memory, Massachusetts Institute of Technology

Nature, 2016, vol. 539, issue 7628, 187-196

Abstract: Abstract Alzheimer's disease is a progressive loss of memory and cognition, for which there is no cure. Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These clinical findings suggest that cognitive decline is the result of a complex pathophysiology and that targeting amyloid-alone may not be sufficient to treat Alzheimer's disease. Instead, a broad outlook on neural-circuit-damaging processes may yield insights into new therapeutic strategies for curing memory loss in the disease.

Date: 2016
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DOI: 10.1038/nature20412

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