PI3Kγ is a molecular switch that controls immune suppression

Megan M. Kaneda, Karen S. Messer, Natacha Ralainirina, Hongying Li, Christopher J. Leem, Sara Gorjestani, Gyunghwi Woo, Abraham V. Nguyen, Camila C. Figueiredo, Philippe Foubert, Michael C. Schmid, Melissa Pink, David G. Winkler, Matthew Rausch, Vito J. Palombella, Jeffery Kutok, Karen McGovern, Kelly A. Frazer, Xuefeng Wu, Michael Karin, Roman Sasik, Ezra E. W. Cohen and Judith A. Varner ()
Additional contact information
Megan M. Kaneda: Moores Cancer Center, University of California, San Diego
Karen S. Messer: Moores Cancer Center, University of California, San Diego
Natacha Ralainirina: Moores Cancer Center, University of California, San Diego
Hongying Li: Moores Cancer Center, University of California, San Diego
Christopher J. Leem: Moores Cancer Center, University of California, San Diego
Sara Gorjestani: Moores Cancer Center, University of California, San Diego
Gyunghwi Woo: Moores Cancer Center, University of California, San Diego
Abraham V. Nguyen: Moores Cancer Center, University of California, San Diego
Camila C. Figueiredo: Moores Cancer Center, University of California, San Diego
Philippe Foubert: Moores Cancer Center, University of California, San Diego
Michael C. Schmid: Moores Cancer Center, University of California, San Diego
Melissa Pink: Infinity Pharmaceuticals
David G. Winkler: Infinity Pharmaceuticals
Matthew Rausch: Infinity Pharmaceuticals
Vito J. Palombella: Infinity Pharmaceuticals
Jeffery Kutok: Infinity Pharmaceuticals
Karen McGovern: Infinity Pharmaceuticals
Kelly A. Frazer: University of California, San Diego
Xuefeng Wu: University of California, San Diego
Michael Karin: University of California, San Diego
Roman Sasik: Center for Computational Biology and Bioinformatics, Institute for Genomic Medicine, University of California, San Diego
Ezra E. W. Cohen: Moores Cancer Center, University of California, San Diego
Judith A. Varner: Moores Cancer Center, University of California, San Diego

Nature, 2016, vol. 539, issue 7629, 437-442

Abstract: Modulation of PI3Kγ activity regulates macrophage polarization during inflammation and cancer, whilst combining PI3Kγ inhibition with immune checkpoint inhibitors leads to synergistic tumour-inhibitory effects.

Date: 2016
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DOI: 10.1038/nature19834

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