Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development

Kelly M. Anderson, Douglas M. Anderson, John R. McAnally, John M. Shelton, Rhonda Bassel-Duby and Eric N. Olson ()
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Kelly M. Anderson: University of Texas Southwestern Medical Center
Douglas M. Anderson: University of Texas Southwestern Medical Center
John R. McAnally: University of Texas Southwestern Medical Center
John M. Shelton: University of Texas Southwestern Medical Center
Rhonda Bassel-Duby: University of Texas Southwestern Medical Center
Eric N. Olson: University of Texas Southwestern Medical Center

Nature, 2016, vol. 539, issue 7629, 433-436

Abstract: Transcription of a long non-coding RNA, known as upperhand (Uph) located upstream of the HAND2 transcription factor is required to maintain transcription of the Hand2 gene by RNA polymerase, and blockade of Uph expression leads to heart defects and embryonic lethality in mice.

Date: 2016
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DOI: 10.1038/nature20128

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