Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs

Ryan J. Cummings, Gaetan Barbet, Gerold Bongers, Boris M. Hartmann, Kyle Gettler, Luciana Muniz, Glaucia C. Furtado, Judy Cho, Sergio A. Lira () and J. Magarian Blander ()
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Ryan J. Cummings: Immunology Institute, Icahn School of Medicine at Mount Sinai
Gaetan Barbet: Immunology Institute, Icahn School of Medicine at Mount Sinai
Gerold Bongers: Immunology Institute, Icahn School of Medicine at Mount Sinai
Boris M. Hartmann: Center for Translational Systems Biology, Icahn School of Medicine at Mount Sinai
Kyle Gettler: Yale School of Medicine
Luciana Muniz: Immunology Institute, Icahn School of Medicine at Mount Sinai
Glaucia C. Furtado: Immunology Institute, Icahn School of Medicine at Mount Sinai
Judy Cho: Immunology Institute, Icahn School of Medicine at Mount Sinai
Sergio A. Lira: Immunology Institute, Icahn School of Medicine at Mount Sinai
J. Magarian Blander: Immunology Institute, Icahn School of Medicine at Mount Sinai

Nature, 2016, vol. 539, issue 7630, 565-569

Abstract: Apoptotic intestinal epithelial cells can be sampled by lamina propria phagocytes, leading to distinct phagocyte-type-specific anti-inflammatory gene signatures and dendritic-cell-mediated induction of regulatory T cells.

Date: 2016
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DOI: 10.1038/nature20138

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