Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation

Claudia Z. Han, Ignacio J. Juncadella, Jason M. Kinchen, Monica W. Buckley, Alexander L. Klibanov, Kelly Dryden, Suna Onengut-Gumuscu, Uta Erdbrügger, Stephen D. Turner, Yun M. Shim, Kenneth S. Tung and Kodi S. Ravichandran ()
Additional contact information
Claudia Z. Han: The Center for Cell Clearance, University of Virginia
Ignacio J. Juncadella: The Center for Cell Clearance, University of Virginia
Jason M. Kinchen: The Center for Cell Clearance, University of Virginia
Monica W. Buckley: The Center for Cell Clearance, University of Virginia
Alexander L. Klibanov: University of Virginia
Kelly Dryden: University of Virginia
Suna Onengut-Gumuscu: University of Virginia
Uta Erdbrügger: University of Virginia
Stephen D. Turner: University of Virginia
Yun M. Shim: University of Virginia
Kenneth S. Tung: University of Virginia
Kodi S. Ravichandran: The Center for Cell Clearance, University of Virginia

Nature, 2016, vol. 539, issue 7630, 570-574

Abstract: Macrophage-derived insulin-like growth factor enhances the uptake of microvesicles by non-professional phagocytes, such as airway epithelial cells and fibroblasts, thereby dampening tissue inflammation.

Date: 2016
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DOI: 10.1038/nature20141

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