An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme

Mary Ortmayer, Pierre Lafite, Binuraj R. K. Menon, Tewes Tralau, Karl Fisher, Lukas Denkhaus, Nigel S. Scrutton, Stephen E. J. Rigby, Andrew W. Munro, Sam Hay and David Leys ()
Additional contact information
Mary Ortmayer: Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester
Pierre Lafite: Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester
Binuraj R. K. Menon: Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester
Tewes Tralau: Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester
Karl Fisher: Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester
Lukas Denkhaus: Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester
Nigel S. Scrutton: Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester
Stephen E. J. Rigby: Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester
Andrew W. Munro: Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester
Sam Hay: Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester
David Leys: Manchester Institute of Biotechnology, School of Chemistry, 131 Princess Street, University of Manchester

Nature, 2016, vol. 539, issue 7630, 593-597

Abstract: Characterization of the first Per-ARNT-Sim enzyme, a haem-dependent oxidative N-demethylase.

Date: 2016
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DOI: 10.1038/nature20159

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