Genetic and mechanistic diversity of piRNA 3′-end formation

Rippei Hayashi, Jakob Schnabl, Dominik Handler, Fabio Mohn, Stefan L. Ameres () and Julius Brennecke ()
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Rippei Hayashi: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC)
Jakob Schnabl: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC)
Dominik Handler: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC)
Fabio Mohn: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC)
Stefan L. Ameres: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC)
Julius Brennecke: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC)

Nature, 2016, vol. 539, issue 7630, 588-592

Abstract: Drosophila have two pathways for PIWI-interacting RNA (piRNA) 3′-end formation—depending on which pathway is used, piRNA biogenesis is directed towards either cytoplasmic or nuclear PIWI protein effectors, which balances post-transcriptional versus transcriptional transposon silencing.

Date: 2016
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DOI: 10.1038/nature20162

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