Designer matrices for intestinal stem cell and organoid culture

Nikolce Gjorevski, Norman Sachs, Andrea Manfrin, Sonja Giger, Maiia E. Bragina, Paloma Ordóñez-Morán, Hans Clevers and Matthias P. Lutolf ()
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Nikolce Gjorevski: Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV) and School of Engineering (STI), Ecole Polytechnique Fédérale de Lausanne (EPFL)
Norman Sachs: Hubrecht Institute and University Medical Center Utrecht
Andrea Manfrin: Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV) and School of Engineering (STI), Ecole Polytechnique Fédérale de Lausanne (EPFL)
Sonja Giger: Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV) and School of Engineering (STI), Ecole Polytechnique Fédérale de Lausanne (EPFL)
Maiia E. Bragina: Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV) and School of Engineering (STI), Ecole Polytechnique Fédérale de Lausanne (EPFL)
Paloma Ordóñez-Morán: Swiss Institute for Experimental Cancer Research (ISREC), EPFL
Hans Clevers: Hubrecht Institute and University Medical Center Utrecht
Matthias P. Lutolf: Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, School of Life Sciences (SV) and School of Engineering (STI), Ecole Polytechnique Fédérale de Lausanne (EPFL)

Nature, 2016, vol. 539, issue 7630, 560-564

Abstract: The authors have designed modular synthetic hydrogel networks for mouse and human intestinal stem cell cultures that support intestinal organoid formation.

Date: 2016
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DOI: 10.1038/nature20168

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