Synthetic recording and in situ readout of lineage information in single cells

Kirsten L. Frieda, James M. Linton, Sahand Hormoz, Joonhyuk Choi, Ke-Huan K. Chow, Zakary S. Singer, Mark W. Budde, Michael B. Elowitz () and Long Cai ()
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Kirsten L. Frieda: California Institute of Technology
James M. Linton: California Institute of Technology
Sahand Hormoz: California Institute of Technology
Joonhyuk Choi: California Institute of Technology
Ke-Huan K. Chow: California Institute of Technology
Zakary S. Singer: California Institute of Technology
Mark W. Budde: California Institute of Technology
Michael B. Elowitz: California Institute of Technology
Long Cai: California Institute of Technology

Nature, 2017, vol. 541, issue 7635, 107-111

Abstract: A new system, termed MEMOIR, allows cells to record lineage and gene expression history within their own genome in a format that can be read out in single cells in situ.

Date: 2017
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DOI: 10.1038/nature20777

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