Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Simone Wahl, Alexander Drong, Benjamin Lehne, Marie Loh, William R. Scott, Sonja Kunze, Pei-Chien Tsai, Janina S. Ried, Weihua Zhang, Youwen Yang, Sili Tan, Giovanni Fiorito, Lude Franke, Simonetta Guarrera, Silva Kasela, Jennifer Kriebel, Rebecca C. Richmond, Marco Adamo, Uzma Afzal, Mika Ala-Korpela, Benedetta Albetti, Ole Ammerpohl, Jane F. Apperley, Marian Beekman, Pier Alberto Bertazzi, S. Lucas Black, Christine Blancher, Marc-Jan Bonder, Mario Brosch, Maren Carstensen-Kirberg, Anton J. M. de Craen, Simon de Lusignan, Abbas Dehghan, Mohamed Elkalaawy, Krista Fischer, Oscar H. Franco, Tom R. Gaunt, Jochen Hampe, Majid Hashemi, Aaron Isaacs, Andrew Jenkinson, Sujeet Jha, Norihiro Kato, Vittorio Krogh, Michael Laffan, Christa Meisinger, Thomas Meitinger, Zuan Yu Mok, Valeria Motta, Hong Kiat Ng, Zacharoula Nikolakopoulou, Georgios Nteliopoulos, Salvatore Panico, Natalia Pervjakova, Holger Prokisch, Wolfgang Rathmann, Michael Roden, Federica Rota, Michelle Ann Rozario, Johanna K. Sandling, Clemens Schafmayer, Katharina Schramm, Reiner Siebert, P. Eline Slagboom, Pasi Soininen, Lisette Stolk, Konstantin Strauch, E-Shyong Tai, Letizia Tarantini, Barbara Thorand, Ettje F. Tigchelaar, Rosario Tumino, Andre G. Uitterlinden, Cornelia van Duijn, Joyce B. J. van Meurs, Paolo Vineis, Ananda Rajitha Wickremasinghe, Cisca Wijmenga, Tsun-Po Yang, Wei Yuan, Alexandra Zhernakova, Rachel L. Batterham, George Davey Smith, Panos Deloukas, Bastiaan T. Heijmans, Christian Herder, Albert Hofman, Cecilia M. Lindgren, Lili Milani, Pim van der Harst, Annette Peters, Thomas Illig, Caroline L. Relton, Melanie Waldenberger, Marjo-Riitta Järvelin, Valentina Bollati, Richie Soong, Tim D. Spector, James Scott, Mark I. McCarthy, Paul Elliott, Jordana T. Bell, Giuseppe Matullo, Christian Gieger, Jaspal S. Kooner (), Harald Grallert () and John C. Chambers ()
Additional contact information
Simone Wahl: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
Alexander Drong: Wellcome Trust Centre for Human Genetics, University of Oxford
Benjamin Lehne: MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
Marie Loh: MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
William R. Scott: MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
Sonja Kunze: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
Pei-Chien Tsai: King’s College London
Janina S. Ried: Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
Weihua Zhang: MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
Youwen Yang: MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
Sili Tan: Cancer Science Institute of Singapore, National University of Singapore
Giovanni Fiorito: Human Genetics Foundation—Torino
Lude Franke: University of Groningen, University Medical Center Groningen
Simonetta Guarrera: Human Genetics Foundation—Torino
Silva Kasela: Estonian Genome Center, University of Tartu, Riia 23b
Jennifer Kriebel: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
Rebecca C. Richmond: MRC Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol
Marco Adamo: UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals
Uzma Afzal: MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
Mika Ala-Korpela: Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu
Benedetta Albetti: EPIGET Lab, Università degli Studi di Milano and Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico
Ole Ammerpohl: Institute of Human Genetics, University Hospital Schleswig-Holstein, Kiel Campus
Jane F. Apperley: Centre for Haematology, Faculty of Medicine, Imperial College London, Hammersmith Campus
Marian Beekman: Molecular Epidemiology, Leiden University Medical Center
Pier Alberto Bertazzi: EPIGET Lab, Università degli Studi di Milano and Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico
S. Lucas Black: Section of Infectious Diseases and Immunity, Imperial College London
Christine Blancher: High Throughput Genomics—Oxford Genomic Centre, Wellcome Trust Centre for Human Genetics, University of Oxford
Marc-Jan Bonder: University of Groningen, University Medical Center Groningen
Mario Brosch: University Hospital of the Technical University Dresden
Maren Carstensen-Kirberg: German Center for Diabetes Research (DZD)
Anton J. M. de Craen: Gerontology and Geriatrics, Leiden University Medical Center
Simon de Lusignan: University of Surrey
Abbas Dehghan: Erasmus Medical Centre
Mohamed Elkalaawy: UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals
Krista Fischer: Estonian Genome Center, University of Tartu, Riia 23b
Oscar H. Franco: Erasmus Medical Centre
Tom R. Gaunt: MRC Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol
Jochen Hampe: University Hospital of the Technical University Dresden
Majid Hashemi: UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals
Aaron Isaacs: Erasmus Medical Centre
Andrew Jenkinson: UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals
Sujeet Jha: Diabetes and Obesity, Max Healthcare
Norihiro Kato: Research Institute, National Center for Global Health and Medicine
Vittorio Krogh: Epidemiology and Prevention Unit, Fondazione IRCSS Istituto Nazionale Tumori
Michael Laffan: Centre for Haematology, Faculty of Medicine, Imperial College London, Hammersmith Campus
Christa Meisinger: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
Thomas Meitinger: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
Zuan Yu Mok: Cancer Science Institute of Singapore, National University of Singapore
Valeria Motta: EPIGET Lab, Università degli Studi di Milano and Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico
Hong Kiat Ng: Cancer Science Institute of Singapore, National University of Singapore
Zacharoula Nikolakopoulou: Vascular Biology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London
Georgios Nteliopoulos: Centre for Haematology, Faculty of Medicine, Imperial College London, Hammersmith Campus
Salvatore Panico: Dipartmento Di Medicina Clinica E Chirurgia Federio II University
Natalia Pervjakova: Estonian Genome Center, University of Tartu, Riia 23b
Holger Prokisch: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
Wolfgang Rathmann: Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf
Michael Roden: German Center for Diabetes Research (DZD)
Federica Rota: EPIGET Lab, Università degli Studi di Milano and Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico
Michelle Ann Rozario: Cancer Science Institute of Singapore, National University of Singapore
Johanna K. Sandling: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Clemens Schafmayer: University Hospital Schleswig-Holstein, Kiel Campus
Katharina Schramm: Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
Reiner Siebert: Institute of Human Genetics, University Hospital Schleswig-Holstein, Kiel Campus
P. Eline Slagboom: Molecular Epidemiology, Leiden University Medical Center
Pasi Soininen: Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu
Lisette Stolk: Erasmus Medical Centre
Konstantin Strauch: Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
E-Shyong Tai: Yong Loo Lin School of Medicine, National University of Singapore
Letizia Tarantini: EPIGET Lab, Università degli Studi di Milano and Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico
Barbara Thorand: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
Ettje F. Tigchelaar: University of Groningen, University Medical Center Groningen
Rosario Tumino: Cancer Registry and Histopathology Unit, ‘Civile—M.P. Arezzo’ Hospital
Andre G. Uitterlinden: Erasmus Medical Centre
Cornelia van Duijn: Erasmus Medical Centre
Joyce B. J. van Meurs: Erasmus Medical Centre
Paolo Vineis: Human Genetics Foundation—Torino
Ananda Rajitha Wickremasinghe: Faculty of Medicine, University of Kelaniya
Cisca Wijmenga: University of Groningen, University Medical Center Groningen
Tsun-Po Yang: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Wei Yuan: King’s College London
Alexandra Zhernakova: University of Groningen, University Medical Center Groningen
Rachel L. Batterham: UCLH Bariatric Centre for Weight Loss, Weight Management and Metabolic and Endocrine Surgery, University College London Hospitals
George Davey Smith: MRC Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol
Panos Deloukas: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
Bastiaan T. Heijmans: Molecular Epidemiology, Leiden University Medical Center
Christian Herder: German Center for Diabetes Research (DZD)
Albert Hofman: Erasmus Medical Centre
Cecilia M. Lindgren: Wellcome Trust Centre for Human Genetics, University of Oxford
Lili Milani: Estonian Genome Center, University of Tartu, Riia 23b
Pim van der Harst: University of Groningen, University Medical Center Groningen
Annette Peters: Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health
Thomas Illig: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
Caroline L. Relton: MRC Integrative Epidemiology Unit (IEU), School of Social and Community Medicine, University of Bristol
Melanie Waldenberger: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
Marjo-Riitta Järvelin: MRC Health Protection Agency (HPE) Centre for Environment and Health, School of Public Health, Imperial College London
Valentina Bollati: EPIGET Lab, Università degli Studi di Milano and Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico
Richie Soong: Cancer Science Institute of Singapore, National University of Singapore
Tim D. Spector: King’s College London
James Scott: National Heart and Lung Institute, Imperial College London
Mark I. McCarthy: Wellcome Trust Centre for Human Genetics, University of Oxford
Paul Elliott: MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
Jordana T. Bell: King’s College London
Giuseppe Matullo: Human Genetics Foundation—Torino
Christian Gieger: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
Jaspal S. Kooner: National Heart and Lung Institute, Imperial College London
Harald Grallert: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
John C. Chambers: MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London

Nature, 2017, vol. 541, issue 7635, 81-86

Abstract: A large-scale epigenome-wide association study identifies changes in DNA methylation associated with body mass index in blood and adipose tissue, and correlates DNA methylation sites with high risk of incident type 2 diabetes.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (11)

Downloads: (external link)
https://www.nature.com/articles/nature20784 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:541:y:2017:i:7635:d:10.1038_nature20784

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature20784

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().