Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans

Caroline Heintz, Thomas K. Doktor, Anne Lanjuin, Caroline C. Escoubas, Yue Zhang, Heather J. Weir, Sneha Dutta, Carlos Giovanni Silva-García, Gitte H. Bruun, Ianessa Morantte, Gerta Hoxhaj, Brendan D. Manning, Brage S. Andresen and William B. Mair ()
Additional contact information
Caroline Heintz: Harvard T. H. Chan School of Public Health
Thomas K. Doktor: and Villum Center for Bioanalytical Sciences, University of Southern Denmark
Anne Lanjuin: Harvard T. H. Chan School of Public Health
Caroline C. Escoubas: Harvard T. H. Chan School of Public Health
Yue Zhang: Harvard T. H. Chan School of Public Health
Heather J. Weir: Harvard T. H. Chan School of Public Health
Sneha Dutta: Harvard T. H. Chan School of Public Health
Carlos Giovanni Silva-García: Harvard T. H. Chan School of Public Health
Gitte H. Bruun: and Villum Center for Bioanalytical Sciences, University of Southern Denmark
Ianessa Morantte: Harvard T. H. Chan School of Public Health
Gerta Hoxhaj: Harvard T. H. Chan School of Public Health
Brendan D. Manning: Harvard T. H. Chan School of Public Health
Brage S. Andresen: and Villum Center for Bioanalytical Sciences, University of Southern Denmark
William B. Mair: Harvard T. H. Chan School of Public Health

Nature, 2017, vol. 541, issue 7635, 102-106

Abstract: Precursor mRNA splicing homeostasis is a biomarker and predictor of life expectancy in Caenorhabditis elegans and defects in global pre-mRNA splicing associated with age are reduced by dietary restriction via splicing factor 1.

Date: 2017
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DOI: 10.1038/nature20789

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