Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

Louise van der Weyden (), Mark J. Arends, Andrew D. Campbell, Tobias Bald, Hannah Wardle-Jones, Nicola Griggs, Martin Del Castillo Velasco-Herrera, Thomas Tüting, Owen J. Sansom, Natasha A. Karp, Simon Clare, Diane Gleeson, Edward Ryder, Antonella Galli, Elizabeth Tuck, Emma L. Cambridge, Thierry Voet, Iain C. Macaulay, Kim Wong, Sarah Spiegel, Anneliese O. Speak and David J. Adams ()
Additional contact information
Louise van der Weyden: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Mark J. Arends: Edinburgh Cancer Research UK Cancer Centre, Institute of Genetics & Molecular Medicine
Andrew D. Campbell: Cancer Research UK Beatson Institute
Tobias Bald: University Hospital Magdeburg
Hannah Wardle-Jones: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Nicola Griggs: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Martin Del Castillo Velasco-Herrera: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Thomas Tüting: University Hospital Magdeburg
Owen J. Sansom: Cancer Research UK Beatson Institute
Natasha A. Karp: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Simon Clare: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Diane Gleeson: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Edward Ryder: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Antonella Galli: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Elizabeth Tuck: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Emma L. Cambridge: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Thierry Voet: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Iain C. Macaulay: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Kim Wong: Wellcome Trust Sanger Institute, Wellcome Genome Campus
Sarah Spiegel: Virginia Commonwealth University School of Medicine
Anneliese O. Speak: Wellcome Trust Sanger Institute, Wellcome Genome Campus
David J. Adams: Wellcome Trust Sanger Institute, Wellcome Genome Campus

Nature, 2017, vol. 541, issue 7636, 233-236

Abstract: Screening mutant mouse lines using a genome-wide in vivo assay identifies microenvironmental regulators of metastatic colonization and defines SPNS2 as an important mediator of lung colonization.

Date: 2017
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DOI: 10.1038/nature20792

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