mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Akinobu Matsumoto, Alessandra Pasut, Masaki Matsumoto, Riu Yamashita, Jacqueline Fung, Emanuele Monteleone, Alan Saghatelian, Keiichi I. Nakayama, John G. Clohessy and Pier Paolo Pandolfi ()
Additional contact information
Akinobu Matsumoto: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School
Alessandra Pasut: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School
Masaki Matsumoto: Medical Institute of Bioregulation, Kyushu University
Riu Yamashita: Tohoku Medical Megabank Organization (ToMMo), Tohoku University
Jacqueline Fung: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School
Emanuele Monteleone: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School
Alan Saghatelian: The Clayton Foundation Laboratories for Peptide Biology, Helmsley Center for Genomic Medicine, Salk Institute for Biological Studies
Keiichi I. Nakayama: Medical Institute of Bioregulation, Kyushu University
John G. Clohessy: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School
Pier Paolo Pandolfi: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School

Nature, 2017, vol. 541, issue 7636, 228-232

Abstract: The polypeptide SPAR is encoded by a long non-coding RNA, localizes to the late endosome and lysosome, and regulates muscle regeneration by inhibiting mTORC1.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/nature21034 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:541:y:2017:i:7636:d:10.1038_nature21034

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature21034

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().