Kinetically E-selective macrocyclic ring-closing metathesis

Xiao Shen, Thach T. Nguyen, Ming Joo Koh, Dongmin Xu, Alexander W. H. Speed, Richard R. Schrock and Amir H. Hoveyda ()
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Xiao Shen: Merkert Chemistry Center, Boston College
Thach T. Nguyen: Merkert Chemistry Center, Boston College
Ming Joo Koh: Merkert Chemistry Center, Boston College
Dongmin Xu: Merkert Chemistry Center, Boston College
Alexander W. H. Speed: Merkert Chemistry Center, Boston College
Richard R. Schrock: Massachusetts Institute of Technology
Amir H. Hoveyda: Merkert Chemistry Center, Boston College

Nature, 2017, vol. 541, issue 7637, 380-385

Abstract: Ring-closing metathesis is a widely used chemical transformation that can generate organic macrocycle compounds; here, an approach is described by which the E-stereoisomer of a macrocycle is generated selectively, exemplified by synthesizing the antibiotic recifeolide and the anti-cancer drug pacritinib.

Date: 2017
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DOI: 10.1038/nature20800

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