Genetic variants regulating expression levels and isoform diversity during embryogenesis

Enrico Cannavò, Nils Koelling, Dermot Harnett, David Garfield, Francesco P. Casale, Lucia Ciglar, Hilary E. Gustafson, Rebecca R. Viales, Raquel Marco-Ferreres, Jacob F. Degner, Bingqing Zhao, Oliver Stegle, Ewan Birney () and Eileen E. M. Furlong ()
Additional contact information
Enrico Cannavò: European Molecular Biology Laboratory (EMBL), Genome Biology Unit
Nils Koelling: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI)
Dermot Harnett: European Molecular Biology Laboratory (EMBL), Genome Biology Unit
David Garfield: European Molecular Biology Laboratory (EMBL), Genome Biology Unit
Francesco P. Casale: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI)
Lucia Ciglar: European Molecular Biology Laboratory (EMBL), Genome Biology Unit
Hilary E. Gustafson: European Molecular Biology Laboratory (EMBL), Genome Biology Unit
Rebecca R. Viales: European Molecular Biology Laboratory (EMBL), Genome Biology Unit
Raquel Marco-Ferreres: European Molecular Biology Laboratory (EMBL), Genome Biology Unit
Jacob F. Degner: European Molecular Biology Laboratory (EMBL), Genome Biology Unit
Bingqing Zhao: European Molecular Biology Laboratory (EMBL), Genome Biology Unit
Oliver Stegle: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI)
Ewan Birney: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI)
Eileen E. M. Furlong: European Molecular Biology Laboratory (EMBL), Genome Biology Unit

Nature, 2017, vol. 541, issue 7637, 402-406

Abstract: The effects of genetic variation on transcriptional and post-transcriptional regulation are systematically mapped across multiple stages of embryogenesis in eighty inbred Drosophila lines, identifying thousands of quantitative trait loci affecting approximately 17% of expressed genes, often with heteroalleic interactions.

Date: 2017
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DOI: 10.1038/nature20802

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