PLA2G16 represents a switch between entry and clearance of Picornaviridae

Jacqueline Staring, Eleonore von Castelmur, Vincent A. Blomen, Lisa G. van den Hengel, Markus Brockmann, Jim Baggen, Hendrik Jan Thibaut, Joppe Nieuwenhuis, Hans Janssen, Frank J. M. van Kuppeveld, Anastassis Perrakis, Jan E. Carette and Thijn R. Brummelkamp ()
Additional contact information
Jacqueline Staring: Netherlands Cancer Institute
Eleonore von Castelmur: Netherlands Cancer Institute
Vincent A. Blomen: Netherlands Cancer Institute
Lisa G. van den Hengel: Netherlands Cancer Institute
Markus Brockmann: Netherlands Cancer Institute
Jim Baggen: Faculty of Veterinary Medicine, Utrecht University
Hendrik Jan Thibaut: Faculty of Veterinary Medicine, Utrecht University
Joppe Nieuwenhuis: Netherlands Cancer Institute
Hans Janssen: Netherlands Cancer Institute
Frank J. M. van Kuppeveld: Faculty of Veterinary Medicine, Utrecht University
Anastassis Perrakis: Netherlands Cancer Institute
Jan E. Carette: Stanford University School of Medicine
Thijn R. Brummelkamp: Netherlands Cancer Institute

Nature, 2017, vol. 541, issue 7637, 412-416

Abstract: The phospholipase PLA2G16 is required for the entry of picornaviruses, and in its absence, virus infection is prevented by a galectin-8-mediated process.

Date: 2017
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DOI: 10.1038/nature21032

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