Structural basis for ArfA–RF2-mediated translation termination on mRNAs lacking stop codons

Paul Huter, Claudia Müller, Bertrand Beckert, Stefan Arenz, Otto Berninghausen, Roland Beckmann and Daniel N. Wilson ()
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Paul Huter: Gene Center, Ludwig-Maximilians-Universität München
Claudia Müller: Gene Center, Ludwig-Maximilians-Universität München
Bertrand Beckert: Gene Center, Ludwig-Maximilians-Universität München
Stefan Arenz: Gene Center, Ludwig-Maximilians-Universität München
Otto Berninghausen: Gene Center, Ludwig-Maximilians-Universität München
Roland Beckmann: Gene Center, Ludwig-Maximilians-Universität München
Daniel N. Wilson: Gene Center, Ludwig-Maximilians-Universität München

Nature, 2017, vol. 541, issue 7638, 546-549

Abstract: The structure of the bacterial ribosome stalled on a truncated mRNA in complex with ArfA and the release factor RF2 is presented, revealing how ArfA recruits RF2 to the ribosome and induces conformational changes within RF2 to enable translation termination in the absence of a stop codon.

Date: 2017
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DOI: 10.1038/nature20821

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