Mechanistic insights into the alternative translation termination by ArfA and RF2

Chengying Ma, Daisuke Kurita, Ningning Li, Yan Chen, Hyouta Himeno () and Ning Gao ()
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Chengying Ma: Ministry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University
Daisuke Kurita: Faculty of Agriculture and Life Science, Hirosaki University
Ningning Li: Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking University
Yan Chen: Ministry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University
Hyouta Himeno: Faculty of Agriculture and Life Science, Hirosaki University
Ning Gao: Ministry of Education Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University

Nature, 2017, vol. 541, issue 7638, 550-553

Abstract: The structure of the bacterial 70S ribosome in complex with ArfA, the release factor RF2, a short non-stop mRNA and a cognate P-site tRNA is presented, revealing how ArfA and RF2 facilitate alternative translation termination of the non-stop ribosomal complex using a stop-codon surrogate mechanism.

Date: 2017
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DOI: 10.1038/nature20822

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