The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

Adrian Britschgi, Stephan Duss, Sungeun Kim, Joana Pinto Couto, Heike Brinkhaus, Shany Koren, Duvini De Silva, Kirsten D. Mertz, Daniela Kaup, Zsuzsanna Varga, Hans Voshol, Alexandra Vissieres, Cedric Leroy, Tim Roloff, Michael B. Stadler, Christina H. Scheel, Loren J. Miraglia, Anthony P. Orth, Ghislain M. C. Bonamy, Venkateshwar A. Reddy and Mohamed Bentires-Alj ()
Additional contact information
Adrian Britschgi: Friedrich Miescher Institute for Biomedical Research
Stephan Duss: Friedrich Miescher Institute for Biomedical Research
Sungeun Kim: Genomics Institute of the Novartis Research Foundation
Joana Pinto Couto: Friedrich Miescher Institute for Biomedical Research
Heike Brinkhaus: Friedrich Miescher Institute for Biomedical Research
Shany Koren: Friedrich Miescher Institute for Biomedical Research
Duvini De Silva: Friedrich Miescher Institute for Biomedical Research
Kirsten D. Mertz: Institute of Pathology Liestal, Cantonal Hospital Baselland
Daniela Kaup: Institute of Pathology Liestal, Cantonal Hospital Baselland
Zsuzsanna Varga: Institute of Surgical Pathology, University Hospital Zurich
Hans Voshol: Novartis Institutes for Biomedical Research
Alexandra Vissieres: Novartis Institutes for Biomedical Research
Cedric Leroy: Friedrich Miescher Institute for Biomedical Research
Tim Roloff: Friedrich Miescher Institute for Biomedical Research
Michael B. Stadler: Friedrich Miescher Institute for Biomedical Research
Christina H. Scheel: Institute of Stem Cell Research, German Research Center for Environmental Health
Loren J. Miraglia: Genomics Institute of the Novartis Research Foundation
Anthony P. Orth: Genomics Institute of the Novartis Research Foundation
Ghislain M. C. Bonamy: Genomics Institute of the Novartis Research Foundation
Venkateshwar A. Reddy: Genomics Institute of the Novartis Research Foundation
Mohamed Bentires-Alj: Friedrich Miescher Institute for Biomedical Research

Nature, 2017, vol. 541, issue 7638, 541-545

Abstract: Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-α, thereby changing human breast cell fate.

Date: 2017
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DOI: 10.1038/nature20829

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