Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

Kristen M. Turner, Viraj Deshpande, Doruk Beyter, Tomoyuki Koga, Jessica Rusert, Catherine Lee, Bin Li, Karen Arden, Bing Ren, David A. Nathanson, Harley I. Kornblum, Michael D. Taylor, Sharmeela Kaushal, Webster K. Cavenee, Robert Wechsler-Reya, Frank B. Furnari, Scott R. Vandenberg, P. Nagesh Rao, Geoffrey M. Wahl, Vineet Bafna () and Paul S. Mischel ()
Additional contact information
Kristen M. Turner: Ludwig Institute for Cancer Research, University of California at San Diego
Viraj Deshpande: University of California at San Diego
Doruk Beyter: University of California at San Diego
Tomoyuki Koga: Ludwig Institute for Cancer Research, University of California at San Diego
Jessica Rusert: Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Catherine Lee: Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Bin Li: Ludwig Institute for Cancer Research, University of California at San Diego
Karen Arden: Ludwig Institute for Cancer Research, University of California at San Diego
Bing Ren: Ludwig Institute for Cancer Research, University of California at San Diego
David A. Nathanson: David Geffen UCLA School of Medicine
Harley I. Kornblum: David Geffen UCLA School of Medicine
Michael D. Taylor: The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Sharmeela Kaushal: Moores Cancer Center, University of California at San Diego
Webster K. Cavenee: Ludwig Institute for Cancer Research, University of California at San Diego
Robert Wechsler-Reya: Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Frank B. Furnari: Ludwig Institute for Cancer Research, University of California at San Diego
Scott R. Vandenberg: University of California San Francisco
P. Nagesh Rao: David Geffen UCLA School of Medicine
Geoffrey M. Wahl: Gene Expression Laboratory, Salk Institute for Biological Studies
Vineet Bafna: University of California at San Diego
Paul S. Mischel: Ludwig Institute for Cancer Research, University of California at San Diego

Nature, 2017, vol. 543, issue 7643, 122-125

Abstract: Circular extrachromosomal DNA is found in nearly half of human cancers of a wide variety of histologic types, increasing the copy number of driver oncogenes and intratumoral heterogeneity more effectively than chromosomal amplification and contributing to tumor evolution.

Date: 2017
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DOI: 10.1038/nature21356

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