Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease

Manoj K. Pandey (), Thomas A. Burrow, Reena Rani, Lisa J. Martin, David Witte, Kenneth D. Setchell, Mary A. Mckay, Albert F. Magnusen, Wujuan Zhang, Benjamin Liou, Jörg Köhl () and Gregory A. Grabowski
Additional contact information
Manoj K. Pandey: Cincinnati Children’s Hospital Medical Center
Thomas A. Burrow: Cincinnati Children’s Hospital Medical Center
Reena Rani: Cincinnati Children’s Hospital Medical Center
Lisa J. Martin: Cincinnati Children’s Hospital Medical Center
David Witte: Cincinnati Children’s Hospital Medical Center
Kenneth D. Setchell: Laboratory of Mass Spectroscopy, Cincinnati Children’s Hospital Medical Center
Mary A. Mckay: Cincinnati Children’s Hospital Medical Center
Albert F. Magnusen: Cincinnati Children’s Hospital Medical Center
Wujuan Zhang: Laboratory of Mass Spectroscopy, Cincinnati Children’s Hospital Medical Center
Benjamin Liou: Cincinnati Children’s Hospital Medical Center
Jörg Köhl: Cincinnati Children’s Hospital Medical Center
Gregory A. Grabowski: Cincinnati Children’s Hospital Medical Center

Nature, 2017, vol. 543, issue 7643, 108-112

Abstract: Complement-activating glycosylceramide-specific autoantibodies drive a self-propagating cycle of glycosylceramide accumulation and inflammation in Gaucher disease.

Date: 2017
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DOI: 10.1038/nature21368

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