Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy

H. Diego Folco, Venkata R. Chalamcharla, Tomoyasu Sugiyama, Gobi Thillainadesan, Martin Zofall, Vanivilasini Balachandran, Jothy Dhakshnamoorthy, Takeshi Mizuguchi and Shiv I. S. Grewal ()
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H. Diego Folco: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Venkata R. Chalamcharla: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Tomoyasu Sugiyama: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Gobi Thillainadesan: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Martin Zofall: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Vanivilasini Balachandran: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Jothy Dhakshnamoorthy: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Takeshi Mizuguchi: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Shiv I. S. Grewal: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health

Nature, 2017, vol. 543, issue 7643, 126-130

Abstract: Uniparental disomy in fission yeast is triggered by aberrant expression of gametogenic genes in vegetative cells, and is associated with the activation of meiotic cohesin Rec8 in cells with defects in the RNA interference machinery.

Date: 2017
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DOI: 10.1038/nature21372

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