Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

Justin Eyquem, Jorge Mansilla-Soto, Theodoros Giavridis, Sjoukje J. C. van der Stegen, Mohamad Hamieh, Kristen M. Cunanan, Ashlesha Odak, Mithat Gönen and Michel Sadelain ()
Additional contact information
Justin Eyquem: Center for Cell Engineering and Immunology Program
Jorge Mansilla-Soto: Center for Cell Engineering and Immunology Program
Theodoros Giavridis: Center for Cell Engineering and Immunology Program
Sjoukje J. C. van der Stegen: Center for Cell Engineering and Immunology Program
Mohamad Hamieh: Center for Cell Engineering and Immunology Program
Kristen M. Cunanan: Memorial Sloan Kettering Cancer Center
Ashlesha Odak: Center for Cell Engineering and Immunology Program
Mithat Gönen: Memorial Sloan Kettering Cancer Center
Michel Sadelain: Center for Cell Engineering and Immunology Program

Nature, 2017, vol. 543, issue 7643, 113-117

Abstract: Introducing chimeric antigen receptors into the endogenous T-cell receptor locus reduces tonic signalling, averts accelerated T-cell differentiation and delays T-cell exhaustion, leading to enhanced function and anti-tumour efficacy compared to random integrations.

Date: 2017
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DOI: 10.1038/nature21405

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