Mechanical stretch triggers rapid epithelial cell division through Piezo1

S. A. Gudipaty, J. Lindblom, P. D. Loftus, M. J. Redd, K. Edes, C. F. Davey, V. Krishnegowda and J. Rosenblatt ()
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S. A. Gudipaty: Huntsman Cancer Institute, University of Utah
J. Lindblom: Huntsman Cancer Institute, University of Utah
P. D. Loftus: Huntsman Cancer Institute, University of Utah
M. J. Redd: Huntsman Cancer Institute, University of Utah
K. Edes: Huntsman Cancer Institute, University of Utah
C. F. Davey: Huntsman Cancer Institute, University of Utah
V. Krishnegowda: Huntsman Cancer Institute, University of Utah
J. Rosenblatt: Huntsman Cancer Institute, University of Utah

Nature, 2017, vol. 543, issue 7643, 118-121

Abstract: The stretch-activated channel Piezo1 controls homeostatic epithelial cell numbers by activating cells to divide rapidly when under stretch strain from low density, and by activating cells to extrude and die when cells are under crowding strain.

Date: 2017
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DOI: 10.1038/nature21407

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