Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

Youdong Pan, Tian Tian, Chang Ook Park, Serena Y. Lofftus, Shenglin Mei, Xing Liu, Chi Luo, John T. O’Malley, Ahmed Gehad, Jessica E. Teague, Sherrie J. Divito, Robert Fuhlbrigge, Pere Puigserver, James G. Krueger, Gökhan S. Hotamisligil, Rachael A. Clark and Thomas S. Kupper ()
Additional contact information
Youdong Pan: Brigham and Women’s Hospital, Boston, Harvard Medical School
Tian Tian: Brigham and Women’s Hospital, Boston, Harvard Medical School
Chang Ook Park: Brigham and Women’s Hospital, Boston, Harvard Medical School
Serena Y. Lofftus: Brigham and Women’s Hospital, Boston, Harvard Medical School
Shenglin Mei: Center for Functional Epigenetics, Dana-Farber Cancer Institute
Xing Liu: Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School
Chi Luo: Dana Farber Cancer Institute, Harvard Medical School
John T. O’Malley: Brigham and Women’s Hospital, Boston, Harvard Medical School
Ahmed Gehad: Brigham and Women’s Hospital, Boston, Harvard Medical School
Jessica E. Teague: Brigham and Women’s Hospital, Boston, Harvard Medical School
Sherrie J. Divito: Brigham and Women’s Hospital, Boston, Harvard Medical School
Robert Fuhlbrigge: Brigham and Women’s Hospital, Boston, Harvard Medical School
Pere Puigserver: Dana Farber Cancer Institute, Harvard Medical School
James G. Krueger: Rockefeller University
Gökhan S. Hotamisligil: Harvard T.H. Chan School of Public Health
Rachael A. Clark: Brigham and Women’s Hospital, Boston, Harvard Medical School
Thomas S. Kupper: Brigham and Women’s Hospital, Boston, Harvard Medical School

Nature, 2017, vol. 543, issue 7644, 252-256

Abstract: FABP4 and FABP5 are important for the maintenance, longevity and function of CD8+ tissue-resident memory T cells, which use oxidative metabolism of exogenous free fatty acids to persist in tissues and to mediate protective immunity.

Date: 2017
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DOI: 10.1038/nature21379

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