Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

Norbert Pardi, Michael J. Hogan, Rebecca S. Pelc, Hiromi Muramatsu, Hanne Andersen, Christina R. DeMaso, Kimberly A. Dowd, Laura L. Sutherland, Richard M. Scearce, Robert Parks, Wendeline Wagner, Alex Granados, Jack Greenhouse, Michelle Walker, Elinor Willis, Jae-Sung Yu, Charles E. McGee, Gregory D. Sempowski, Barbara L. Mui, Ying K. Tam, Yan-Jang Huang, Dana Vanlandingham, Veronica M. Holmes, Harikrishnan Balachandran, Sujata Sahu, Michelle Lifton, Stephen Higgs, Scott E. Hensley, Thomas D. Madden, Michael J. Hope, Katalin Karikó, Sampa Santra, Barney S. Graham, Mark G. Lewis, Theodore C. Pierson, Barton F. Haynes and Drew Weissman ()
Additional contact information
Norbert Pardi: Perelman School of Medicine, University of Pennsylvania
Michael J. Hogan: Perelman School of Medicine, University of Pennsylvania
Rebecca S. Pelc: Viral Pathogenesis Section, National Institute of Allergy and Infectious Disease, National Institutes of Health
Hiromi Muramatsu: Perelman School of Medicine, University of Pennsylvania
Hanne Andersen: Bioqual Inc.
Christina R. DeMaso: Viral Pathogenesis Section, National Institute of Allergy and Infectious Disease, National Institutes of Health
Kimberly A. Dowd: Viral Pathogenesis Section, National Institute of Allergy and Infectious Disease, National Institutes of Health
Laura L. Sutherland: Duke Human Vaccine Institute, Duke University School of Medicine
Richard M. Scearce: Duke Human Vaccine Institute, Duke University School of Medicine
Robert Parks: Duke Human Vaccine Institute, Duke University School of Medicine
Wendeline Wagner: Bioqual Inc.
Alex Granados: Bioqual Inc.
Jack Greenhouse: Bioqual Inc.
Michelle Walker: Bioqual Inc.
Elinor Willis: Perelman School of Medicine, University of Pennsylvania
Jae-Sung Yu: Duke Human Vaccine Institute, Duke University School of Medicine
Charles E. McGee: Duke Human Vaccine Institute, Duke University School of Medicine
Gregory D. Sempowski: Duke Human Vaccine Institute, Duke University School of Medicine
Barbara L. Mui: Acuitas Therapeutics, Vancouver
Ying K. Tam: Acuitas Therapeutics, Vancouver
Yan-Jang Huang: Diagnostic Medicine and Pathobiology, College of Veterinary Medicine and the Biosecurity Research Institute, Kansas State University
Dana Vanlandingham: Diagnostic Medicine and Pathobiology, College of Veterinary Medicine and the Biosecurity Research Institute, Kansas State University
Veronica M. Holmes: Perelman School of Medicine, University of Pennsylvania
Harikrishnan Balachandran: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Sujata Sahu: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Michelle Lifton: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Stephen Higgs: Diagnostic Medicine and Pathobiology, College of Veterinary Medicine and the Biosecurity Research Institute, Kansas State University
Scott E. Hensley: Perelman School of Medicine, University of Pennsylvania
Thomas D. Madden: Acuitas Therapeutics, Vancouver
Michael J. Hope: Acuitas Therapeutics, Vancouver
Katalin Karikó: BioNTech RNA Pharmaceuticals
Sampa Santra: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Barney S. Graham: Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health
Mark G. Lewis: Bioqual Inc.
Theodore C. Pierson: Viral Pathogenesis Section, National Institute of Allergy and Infectious Disease, National Institutes of Health
Barton F. Haynes: Duke Human Vaccine Institute, Duke University School of Medicine
Drew Weissman: Perelman School of Medicine, University of Pennsylvania

Nature, 2017, vol. 543, issue 7644, 248-251

Abstract: A single, low-dose intradermal immunization with lipid-nanoparticle-encapsulated nucleoside-modified mRNA encoding the pre-membrane and envelope glycoproteins of Zika virus protects both mice and rhesus macaques against infection and elicits rapid and long-lasting neutralizing antibody responses.

Date: 2017
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DOI: 10.1038/nature21428

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