ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia

Liling Wan, Hong Wen, Yuanyuan Li, Jie Lyu, Yuanxin Xi, Takayuki Hoshii, Julia K. Joseph, Xiaolu Wang, Yong-Hwee E. Loh, Michael A. Erb, Amanda L. Souza, James E. Bradner, Li Shen, Wei Li, Haitao Li, C. David Allis (), Scott A. Armstrong () and Xiaobing Shi ()
Additional contact information
Liling Wan: Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University
Hong Wen: The University of Texas MD Anderson Cancer Center
Yuanyuan Li: Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University
Jie Lyu: Dan L. Duncan Cancer Center, Baylor College of Medicine
Yuanxin Xi: Dan L. Duncan Cancer Center, Baylor College of Medicine
Takayuki Hoshii: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
Julia K. Joseph: Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University
Xiaolu Wang: The University of Texas MD Anderson Cancer Center
Yong-Hwee E. Loh: Icahn School of Medicine at Mount Sinai
Michael A. Erb: Dana-Farber Cancer Institute
Amanda L. Souza: Dana-Farber Cancer Institute
James E. Bradner: Dana-Farber Cancer Institute
Li Shen: Icahn School of Medicine at Mount Sinai
Wei Li: Dan L. Duncan Cancer Center, Baylor College of Medicine
Haitao Li: Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University
C. David Allis: Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University
Scott A. Armstrong: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
Xiaobing Shi: The University of Texas MD Anderson Cancer Center

Nature, 2017, vol. 543, issue 7644, 265-269

Abstract: The chromatin-reader protein ENL regulates oncogenic programs in acute myeloid leukaemia by binding via its YEATS domain to acetylated histones on the promoters of actively transcribed genes and recruiting the transcriptional machinery.

Date: 2017
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DOI: 10.1038/nature21687

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