Transcription control by the ENL YEATS domain in acute leukaemia

Michael A. Erb, Thomas G. Scott, Bin E. Li, Huafeng Xie, Joshiawa Paulk, Hyuk-Soo Seo, Amanda Souza, Justin M. Roberts, Shiva Dastjerdi, Dennis L. Buckley, Neville E. Sanjana, Ophir Shalem, Behnam Nabet, Rhamy Zeid, Nana K. Offei-Addo, Sirano Dhe-Paganon, Feng Zhang, Stuart H. Orkin, Georg E. Winter and James E. Bradner ()
Additional contact information
Michael A. Erb: Dana-Farber Cancer Institute
Thomas G. Scott: Dana-Farber Cancer Institute
Bin E. Li: Boston Children’s Hospital
Huafeng Xie: Boston Children’s Hospital
Joshiawa Paulk: Dana-Farber Cancer Institute
Hyuk-Soo Seo: Dana-Farber Cancer Institute
Amanda Souza: Dana-Farber Cancer Institute
Justin M. Roberts: Dana-Farber Cancer Institute
Shiva Dastjerdi: Dana-Farber Cancer Institute
Dennis L. Buckley: Dana-Farber Cancer Institute
Neville E. Sanjana: Broad Institute, 7 Cambridge Center
Ophir Shalem: Broad Institute, 7 Cambridge Center
Behnam Nabet: Dana-Farber Cancer Institute
Rhamy Zeid: Dana-Farber Cancer Institute
Nana K. Offei-Addo: Dana-Farber Cancer Institute
Sirano Dhe-Paganon: Dana-Farber Cancer Institute
Feng Zhang: Broad Institute, 7 Cambridge Center
Stuart H. Orkin: Boston Children’s Hospital
Georg E. Winter: Dana-Farber Cancer Institute
James E. Bradner: Dana-Farber Cancer Institute

Nature, 2017, vol. 543, issue 7644, 270-274

Abstract: ENL, identified in a genome-scale loss-of-function screen as a crucial requirement for proliferation of acute leukaemia, is required for leukaemic gene expression, and its YEATS chromatin-reader domain is essential for leukaemic growth.

Date: 2017
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DOI: 10.1038/nature21688

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