SZT2 dictates GATOR control of mTORC1 signalling

Min Peng, Na Yin and Ming O. Li
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Min Peng: Immunology Program, Memorial Sloan Kettering Cancer Center
Na Yin: Immunology Program, Memorial Sloan Kettering Cancer Center
Ming O. Li: Immunology Program, Memorial Sloan Kettering Cancer Center

Nature, 2017, vol. 543, issue 7645, 433-437

Abstract: SZT2 recruits GATOR1 and GATOR2 to form a SZT2-orchestrated GATOR (SOG) complex at the lysosome that is essential for GATOR- and SESN-dependent nutrient sensing and mTORC1 regulation.

Date: 2017
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DOI: 10.1038/nature21378

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