Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

Jennifer L. Guerriero, Alaba Sotayo, Holly E. Ponichtera, Jessica A. Castrillon, Alexandra L. Pourzia, Sara Schad, Shawn F. Johnson, Ruben D. Carrasco, Suzan Lazo, Roderick T. Bronson, Scott P. Davis, Mercedes Lobera, Michael A. Nolan () and Anthony Letai ()
Additional contact information
Jennifer L. Guerriero: Dana-Farber Cancer Institute
Alaba Sotayo: Dana-Farber Cancer Institute
Holly E. Ponichtera: Dana-Farber Cancer Institute
Jessica A. Castrillon: Dana-Farber Cancer Institute
Alexandra L. Pourzia: Dana-Farber Cancer Institute
Sara Schad: Dana-Farber Cancer Institute
Shawn F. Johnson: Dana-Farber Cancer Institute
Ruben D. Carrasco: Brigham and Women’s Hospital
Suzan Lazo: Dana-Farber Cancer Institute
Roderick T. Bronson: Harvard Medical School
Scott P. Davis: GlaxoSmithKline
Mercedes Lobera: GlaxoSmithKline
Michael A. Nolan: GlaxoSmithKline
Anthony Letai: Dana-Farber Cancer Institute

Nature, 2017, vol. 543, issue 7645, 428-432

Abstract: A selective class IIa histone deacetylase inhibitor induces anti-tumour immunity in a mouse model of mammary cancer through altered differentiation and recruitment of tumour-associated macrophages.

Date: 2017
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DOI: 10.1038/nature21409

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