KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

Rachel L. Wolfson, Lynne Chantranupong, Gregory A. Wyant, Xin Gu, Jose M. Orozco, Kuang Shen, Kendall J. Condon, Sabrina Petri, Jibril Kedir, Sonia M. Scaria, Monther Abu-Remaileh, Wayne N. Frankel and David M. Sabatini ()
Additional contact information
Rachel L. Wolfson: Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
Lynne Chantranupong: Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
Gregory A. Wyant: Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
Xin Gu: Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
Jose M. Orozco: Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
Kuang Shen: Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
Kendall J. Condon: Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
Sabrina Petri: Columbia University Medical Center
Jibril Kedir: Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
Sonia M. Scaria: Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
Monther Abu-Remaileh: Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center
Wayne N. Frankel: Columbia University Medical Center
David M. Sabatini: Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, 9 Cambridge Center

Nature, 2017, vol. 543, issue 7645, 438-442

Abstract: A protein complex composed of KPTN, ITFG2, C12orf66 and SZT2, named KICSTOR, is necessary for lysosomal localization of GATOR1, interaction of GATOR1 with the Rag GTPases and GATOR2, and nutrient-dependent mTORC1 modulation.

Date: 2017
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DOI: 10.1038/nature21423

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